BACKGROUND Left ventricular hypertrophy has multiple aetiologies including diabetes and genetic factors. We aimed to identify genetic variants predicting left ventricular hypertrophy in diabetic individuals. METHODS Demographic, echocardiographic, prescribing, morbidity, mortality and genotyping databases connected with the Genetics of Diabetes Audit and Research in Tayside, Scotland project ...

Overexpression of IL-6 has been implicated in the pathology of numerous autoimmune and chronic inflammatory diseases, including psoriasis, and relative deficiency of IL-10 in psoriatic patients seems to be important in the development of this disease. The aim of this study was to investigate the association between IL-6 and IL-10 single nucleotide polymorphisms and susceptibility to psoriasis v...

BACKGROUND Thymidylate synthase and hypoxia inducible factor-1α play a central role in the control of tumor progression. In the present study, we investigated the effect of three DNA polymorphisms within the thymidylate synthase gene and two within hypoxia inducible factor-1α on the prognosis of pancreatic cancer. PATIENTS AND METHODS A retrospective study was performed in 59 patients diagnos...

Bacillus subtilis Miz-8 is isolated from Bekang, a traditional fermented soybean food of Mizoram, India. Here, we report computationally analyzed strain mapped to the annotated genome reference subsp. natto BEST195. has circular chromosome and small plasmid with size 4105264 bp 5838 bp, respectively. Genome contains genes responsible for synthesis biosynthetic metabolites like surfactin, fengyc...

The BCR-ABL K247R change is based on a rare single nucleotide polymorphism occurring likewise in healthy controls and non-hematologic cell types. Despite its juxtaposition to the P-loop, functional analysis showed no alteration compared to non-mutated BCR-ABL. We sought to investigate if other changes in the BCR-ABL kinase domain should be considered as single nucleotide polymorphisms rather th...

Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is a complex disease to study because of the potential role of demographic, environmental, and other systemic risk factors, such as age, sex, race, light exposure, diet, smoking, and underlying cardiovascular disease which may contribute to the pathogenesis of this disease. Recently, single nucleotide polymor...

We have determined the complete chloroplast genome of <i>Erigeron canadensis</i> isolated in Korea. The circular <i>E. is 152,767 bp long and has four subregions: 84,317 large single-copy 18,446 small regions are separated by 25,004 inverted repeat including 133 genes (88 protein-coding genes, eight rRNAs, 37 tRNAs). Korea differs from Chinese isolate 103 single-nucleotide pol...

Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was perfor...

Purpose: Polycystic Ovary Syndrome (PCOS) is a complex multifactorial endocrine metabolic disorder of reproductive-aged women characterized by hyperandrogenism, hirsutism, anovulation, hyperinsulinemia and polycystic ovaries. The main aim this study was to investigate the association eNOS STAT6 gene Single Nucleotide Polymorphisms (SNPs) with susceptibility PCOS in South Indian Women. Research ...

The TAS2R38 gene is involved in bitter taste perception. This study documents the distinctive diversity patterns northern Africa of functional single-nucleotide polymorphisms (SNPs) rs713598 and rs1726866 at locus places those context global diversity. Data previously genotyped with TaqMan assay were analyzed for 375 unrelated subjects (305 Tunisians from seven locations: Mahdia, Sousse, Kesra,...