MOTIVATION The sequence patterns contained in the available motif and hidden Markov model (HMM) databases are a valuable source of information for protein sequence annotation. For structure prediction and fold recognition purposes, we computed mappings from such pattern databases to the protein domain hierarchy given by the ASTRAL compendium and applied them to the prediction of SCOP classifica...

Sequence alignment programs such as BLAST and PSI-BLAST are used routinely in pairwise, profile-based, or intermediate-sequence-search (ISS) methods to detect remote homologies for the purposes of fold assignment and comparative modeling. Yet, the sequence alignment quality of these methods at low sequence identity is not known. We have used the CE structure alignment program (Shindyalov and Bo...

sainfoin (onobrychis viciifolia scop.) is a perennial forage legume has recognized for its feed value and high stability. this experiment was conducted to investigate the relationship among morphological and agronomic traits using multivariate statistical methods including correlation, regression and factor analysis. twenty one accessions of sainfoin were evaluated in a randomized complete bloc...

In this paper we discuss the problem of attaining a dynamic compromise between using redundancy to improve software dependability and limiting the amount of redundancy so as to avoid unnecessary inefficiencies. A scheme, called self-configuring optimal programming (SCOP), is developed. SCOP attempts to reduce the resource cost of faulttolerant software, both in space and time, by providing desi...

The Structural Classification of Proteins (SCOP) database provides a detailed and comprehensive description of the relationships of all known protein structures. The classification is on hierarchical levels: the first two levels, family and superfamily, describe near and far evolutionary relationships; the third, fold, describes geometrical relationships. The distinction between evolutionary re...

UNLABELLED Several methods for establishing cross-links between Protein Data Bank (PDB) structures or Structural Classification of Proteins (SCOP) domains and Swiss-Prot + TrEMBL sequences (or vice versa) rely on database annotations. Alternatively, sequence alignment procedures can be used. In this study, we describe Seq2Struct, a web resource for the identification of sequence-structure links...

Background: Memory loss is the main disorder accompanied by Alzheimer's disease (AD). Objectives: We aimed to investigate protective effects of aminoguanidine (Amg) on cell apoptosis in hippocampal CA1 region and memory impairment male rats received scopolamine (Scop). Methods: Thirty Wistar (200 - 250 g) were randomly divided into three groups saline-saline group, Scop + saline, Amg groups. Th...