A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.

According to Ross (1), there are three main areas in which organotin compounds have product and process utility: (1) heat stabilizers; (2) catalytic agents; (3) biocidal compounds. Organotin derivatives account for the fourth largest production of organometallics amounting to about 3-4 million pounds per year as compared with about 485 million pounds per year for organolead compounds. Originall...

A selective and sensitive turn-on fluorescent NIR probe for cysteine has been developed. Cleavage of 2,4-dinitrobenzenesulfonyl (DNBS) with thiols switches the weakly fluorescent aza-BODIPY dye (λ(em) = 734 nm, Φ(f) = 0.03) to a strongly fluorescent species in the NIR region (λ(em) = 755 nm, Φ(f) = 0.14).