Colchicine overdose is rare but potentially a life threatening toxicological emergency. The severity of colchicine toxicity does not necessarily correlate with the amount of colchicine ingested and may depend on co-ingested agents. Some patients require intensive care. We report two cases of colchicine overdose with unusual presentations requiring intensive care. Case 1: A 37-year-old man took ...

Objective To evaluate the impact of state supported overdose education and nasal naloxone distribution (OEND) programs on rates of opioid related death from overdose and acute care utilization in Massachusetts. Design Interrupted time series analysis of opioid related overdose death and acute care utilization rates from 2002 to 2009 comparing community-year strata with high and low rates of OEN...

Preliminary estimates of U.S. drug overdose deaths exceeded 60,000 in 2016 and were partially driven by a fivefold increase in overdose deaths involving synthetic opioids (excluding methadone), from 3,105 in 2013 to approximately 20,000 in 2016 (1,2). Illicitly manufactured fentanyl, a synthetic opioid 50-100 times more potent than morphine, is primarily responsible for this rapid increase (3,4...

Intentional iron overdose in adults is uncommon. Clinical consequences are variable and depend on the quantity of iron ingested and the delay to treatment. Severe iron overdose can lead to multi-organ failure and acute hepatic necrosis. Here, we report three cases of polypharmacy overdose including iron resulting in acute liver failure. Despite maximum supportive care including liver transplant...

Isoniazid is the mainstay of antitubercular therapy and is included in nearly every drug regime. Cases of intentional and accidental overdose have been reported(l,2) though with less than expected frequency considering the drug's extensive use. The principal manifestations of isoniazid overdose include recurrent seizures, metabolic acidosis and coma(3,4). We report two cases of isoniazid overdo...

Naloxone, an opiate antagonist that can avert opiate overdose mortality, has only recently been prescribed to drug users in a few jurisdictions (Chicago, Baltimore, New Mexico, New York City, and San Francisco) in the United States. This report summarizes the first systematic evaluation of large-scale naloxone distribution among injection drug users (IDUs) in the United States. In 2005, we cond...

BACKGROUND Literature regarding acute human toxicity of mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS) is limited. OBJECTIVES Our objectives were to describe all cases of overdose with MMF or EC-MPS reported to the Swiss Toxicological Information Centre (STIC) or in the literature between 1995 and 2013. Therefore, we performed an observational case-series and sys...

BACKGROUND Repeated drug overdose is a major risk factor for suicide. Data are lacking on the effect of psychiatric intervention on preventing repeated drug overdose. AIMS To investigate whether psychiatric intervention was associated with reduced readmission to emergency centres due to drug overdose. METHOD Using a Japanese national in-patient database, we identified patients who were firs...