نتایج جستجو برای: penetrant agent
تعداد نتایج: 254784 فیلتر نتایج به سال:
Results 158 TRAPS pts were enrolled from November 2009 to June 2012. analyzed. The majority of pts were adults (105, 67%). The median age at disease onset and at disease diagnosis were 4.1 (range 0.2-63 years) and 25.9 (0-77) years, respectively. The median delay of diagnosis was 10.3 years, with a rate of delay 10 times higher in adult patients. Patients were enrolled by 18 centers in 11 count...
in this paper, a formal model for antivirus update agent system is presented based on mobile agent technology and predicate/transition petri nets. the mobile agent system contains two mobile agents called dca and una. it sends out agents to update antivirus on client computers in a network. each agent takes on a specified responsibility. first, dca roams through the network and check the last d...
Cowden syndrome (multiple hamartoma syndrome, MIM 158350) is an early onset syndrome characterized by multiple hamartomas in the skin, mucous membranes, breast, thyroid and endometrium. Patients with Cowden syndrome have increased risk of breast cancer, thyroid cancer and endometrial cancer. In 1997 germline mutations in PTEN were demonstrated to cause Cowden syndrome. We report the results of ...
F irst described by Guido Fanconi in 1927, Fanconi anemia (FA) is now one of the best defined inherited bone marrow failure syndromes. It is usually inherited as an autosomal recessive trait, but in a small subset of FA cases it can be an X-linked recessive disorder. FA patients show marked clinical heterogeneity. Characteristic features include the progressive development of bone marrow failur...
A duplexed, functional multiaddition high throughput screen and subsequent iterative parallel synthesis effort identified the first highly selective and CNS penetrant glucagon-like peptide-1R (GLP-1R) positive allosteric modulator (PAM). PAM (S)-9b potentiated low-dose exenatide to augment insulin secretion in primary mouse pancreatic islets, and (S)-9b alone was effective in potentiating endog...
In the first half of the article, inspection organization and programs are briefly dealt with. This is followed by a more detailed review of inspection, detection and monitoring methods, which comprises visual inspection, radiography, ultrasonic testing, eddy current technique, magnetic particle inspection, the use of liquid penetrant, the electric field signature method, acoustic emission, lea...
Two inherent challenges in the mechanistic interpretation of protease-deficient phenotypes are defining specific substrate cleavages whose reduction generates and determining whether result from loss function, accumulation, or a function(s) embodied fragments. Hence, recapitulation phenotype by cleavage-resistant would stringently validate importance proteolytic event clarify underlying mechani...
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