Acinetobacter baumannii is a gram-negative, non-motile bacterium that, due to its multidrug resistance, has become a major nosocomial pathogen. The increasing number of multidrug resistant (MDR) strains has renewed interest in phage therapy. The aim of our study was to assess the effectiveness of phage administration in Acinetobacter baumannii wound infections in an animal model to demonstrate ...

Understanding the mutual interactions of bacterial and phage populations in the environment of a human or animal body is essential in any attempt to influence these complex processes, particularly for rational phage therapy. Current knowledge on the impact of naturally occurring bacteriophages on the populations of their host bacteria, and their role in the homeostasis maintenance of a macro ho...

conclusions the overall results indicated that bacteriophages isolated from sewage exhibited excellent lytic activity against mrsa strains. in conclusion, bacteriophages can be further characterized and appear to be a promising candidate for phage therapy against mrsa in the future. results the phages exhibited good lytic activity against mrsa when tested in-vitro, and the highest activity was ...

Gene therapy has long been regarded as a promising treatment for cancer. However, cancer gene therapy is still facing the challenge of targeting gene delivery vectors specifically to tumors when administered via clinically acceptable non-invasive systemic routes (i.e. intravenous). The bacteria virus, bacteriophage (phage), represents a new generation of promising vectors in systemic gene deliv...

With the increasing frequency of antibiotic resistance and the decreasing frequency of new antibiotics entering the market, interest has returned to developing bacteriophage as a therapeutic agent. Acceptance of phage therapy, however, is limited by the unknown pharmacodynamics of a replicating agent, as well as the potential for the evolution of resistant bacteria. One way to overcome some of ...

The article describes armed conflicts on the territory of Iraq and Afghanistan. Improvement individual collective protection equipment has reduced number cases soft tissue wounds in extremities. main cause mortality wound complications is antibiotic-resistant microflora. Purulent lead to chronic treatment healing process a long period specialized rehabilitation, which entails difficulties socia...