the insulin-like growth factor i receptor (igf-ir) plays an essential role in the establishment and maintenance of transformed phenotype. interference with the igf-ir pathway by antisense causes reversal of the transformed phenotype in many rodent and human tumor cell lines. we stably transfected the pc-3 human prostate cancer cell line with an igf-ir antisense rna expression plasmid. the numbe...

background and objectives: macrolide, lincosamide and streptogramin type b (mlsb) antibiotics are important in the treatment of staphylococcus aureus infections and existence of isolates with ability to resist against mlsb antibiotics is worrisome. materials and methods: in this cross sectional study, 101 s. aureus isolates were collected from patients of five selected hospitals in tehran over ...

there is no functional annotation for the majority of the several hundreds of receptor-like kinases in plants. a direct way of inferring the function of these proteins is to study the phenotype that results from loss of function mutants such as t-dna mutant lines. in this research a function (phenotype) to at2g37050 gene that encodes a receptor like kinase in arabidopsis t-dna line was assigned...

Nine cases of early erythroblastic leukemia. unidentified by usual criteria, have been diagnosed using a panel of antibodies. Three cases arose in patients with Down’s syndrome, one in a patient with therapy-related leukemia, and four patients were in blast crisis of chronic myeloid leukemia; only one case arose de novo. Blast cells could be assigned to two main stages of erythroid differentiat...

Genetic variation of the enzyme, adenosine deaminase (ADA), can be detected by starch gel electrophoresis of human red cell lysates and an appropriate staining procedure (Spencer, Hopkinson, and Harris, 1968). Three phenotypes (ADA 1, ADA 2-1, and ADA 2) appear to be determined by two structural alleles, ADA' and ADA2. The frequency of the less common allele, ADA2, was reported to be 0 03 and 0...