In this study, a hydrogel composed of acrylamide (AAm) with N-vinylimidazole (NVI) as co-monomer, with a cross-linker such as N, N` Methylenebisacrylamide and potassium peroxodisulfate as an initiator solution was prepared. Poly (AAm/NVI) hydrogels were synthesized by free radical solution polymerization. Swelling experiments were performed in water at 25°C, gravimetrically. Here, it was of...

A composite based on poly(N-vinylpyrrolidone) (PVP) and sodium bentonite was prepared by a simple method. Structural characterizations of the bentonite and the composite were performed by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The TGA analysis showed a low loading of the polymer in the bentonite. XRD analysis confirmed a mod...

Recently, it was reported that the physical crosslinking exhibited by some biopolymers could provide multiple benefits to biomedical applications. In particular, grafting thermoresponsive polymers onto may enhance degradability or offer other features, as thermothickening behavior. Thus, different interactions will affect hydrogen bonds and from of carboxymethyl cellulose, lower critical soluti...

In this study silver/poly vinyl alcohol (PVA) and silver/poly vinyl pyrrolidone (PVP) Nanocomposites were prepared via reduction of silver salt by employing DMF (N, N`- dimethyl formamide) as a reducing agent. Effects of protective agents such as PVA and PVP were also described here. We show that the acidic pH of PVP solution also affects the interaction between protective agents and silver nan...

Signaling pathways of VEGFs and PDGFs are crucial in tumor angiogenesis, which is essential in solid tumor progression and metastasis. This study reports our strategy for designing and synthesizing a series of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential multi-target tyrosine kinase receptor inhibitors. The target compounds were obtained by condensati...

The first immobilization of a MacMillan's first generation organocatalyst onto dendritic support is described. A modified tyrosine-based imidazolidin-4-one was grafted to a soluble high-loading hyperbranched polyglycerol via a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction and readily purified by dialysis. The efficiency of differently functionalized multivalent organocatalysts 4a...

A distamycin model containing an isosteric diazine linked pyrrole has been designed and synthesized. The key steps of the synthesis involved the successful diazotization of the 4-amino-pyrrole derivatives to give the diazomium salts, which undergo coupling reactions with N-methylpyrrole to yield the directly linked diazine compounds. The amide isosteric-diazine pyrrole I demonstrated photo-indu...