Low (or poor) responder patients are women who require large Background: doses of stimulation medications and produce less than an optimal number of oocytes during IVF cycles. Low responder patients produce few oocytes and embryos, which significantly reduces their chances for success in a preimplantation genetic diagnosis (PGD) cycle. Accumulation of vitrified oocytes or embryos before the act...

Infrastructure security against possible attacks involves making decisions under uncertainty. This paper presents game theoretic models of the interaction between an adversary and a first responder in order to study problem of the security within a transportation infrastructure. The risk measure used is based on the consequence of an attack in terms of the number of people affected or the occup...

BACKGROUND Low (or poor) responder patients are women who require large doses of stimulation medications and produce less than an optimal number of oocytes during IVF cycles. Low responder patients produce few oocytes and embryos, which significantly reduces their chances for success in a preimplantation genetic diagnosis (PGD) cycle. Accumulation of vitrified oocytes or embryos before the actu...

INTRODUCTION Hepatitis C virus (HCV), which is a major cause of liver diseases worldwide, undergoes genetic variation during the course of infection. The aim of this study was to examine sequence variations within the HVR1 region of HCV genotype 4 in infected Saudi patients treated with a combination therapy of interferon-α and ribavirin. METHODOLOGY cDNA of the HVR1 region of HVC-4 from one ...

To test whether the antigen-specific stimulation of low responder-genotype B cells in tetraparental mice is due to a histoincompatibility reaction (allogeneic effect) against these B cells, tetraparental mice were constructed (a) between an Ir-1A low responder to the antigen poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys. [(T,G)-A--L] and an Ir-1A F1 high responder and (b) between two histoincompatib...

UNLABELLED Omalizumab is an anti-IgE monoclonal antibody available since 2006 for the treatment of GINA step 4 asthma. We studied a 41-year old male who has been suffering from severe steroid-resistant asthma with severe co-morbidity and treated with Omalizumab. He was found to be non-responder to the treatment until the 48th week, starting from which we began to see a distinct improvement in t...

For some years there has been intense interest in the problem of cellular expression of immune response (Ir) 1 genes. Initial experiments suggested that T cells alone were responsible for Ir manifestations since, for example, mice which were low responders to poly-L-(Tyr,Glu)-poly-D,L-Ala--poly L-Lys [(TG)-A--L] could make antibodies to this antigen coupled to methylated bovine serum albumin (1...