The ovarian steroid hormone, progesterone, and its nuclear receptor, the progesterone receptor, are implicated in the progression of breast cancer. Clinical trial data on the effects of hormone replacement therapy underscore the importance of understanding how progestins influence breast cancer growth. The progesterone receptor regulation of distinct target genes is mediated by complex interact...

Objective(s): The aim of this study is to determine the effects of progesterone treatment on the survival of random skin flaps. Materials and Methods: McFarlane flaps were established and 40 male rats were randomly assigned to the progesterone-treated as the test group or normal saline-treated as the control group. Progesterone or normal saline (10 mg/kg) was administered intraperitoneally onc...

Injections of progesterone induce incubation behavior in gonadally intact ring doves only if the doves have had previous experience with at least the nest-building phase of a breeding cycle. The present study was designed to determine whether exposure to progesterone during the nest-building phase is sufficient to account for the ability of progesterone to induce incubation at a later time or w...

Fatty acid synthase (FAS), a nutritionally regulated lipogenic enzyme, is transcriptionally controlled by ADD1/SREBP1c (adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c), through insulin-mediated stimulation of ADD1/SREBP1c expression. Progesterone exerts lipogenic effects on adipocytes, and FAS is highly induced in breast tumor cell lines upon progeste...

Progesterone powerfully inhibits GnRH secretion in ewes, as in other species, but the neural mechanisms underlying this effect remain poorly understood. Visualization of the neural ovine progesterone receptor has proved elusive but, using a high temperature antigen unmasking technique, the progesterone receptor was revealed in the ewe brain. Progesterone receptors were located in the preoptic-h...

BACKGROUND Although the MMP-2 promoter lacks a canonical progesterone response element (PRE), the hormone inhibits MMP-2 expression and is part of treatment protocols in gynecological invasive pathologies, including endometriosis and endometrial hyperplasia. This study aimed to explore the mechanism by which progesterone inhibits MMP-2 expression. METHODS The effect of progesterone on MMP-2 e...

conclusions patients with apd may have very different symptoms requiring immediate care; therefore, being informed about this condition is necessary for the physicians in emergency and obstetrics and gynecology departments. also a positive history of such condition in a pregnant woman necessitates precautions in the management of her pregnancy due to the potential of anaphylactic events. introd...

Ex v/vo addition of estradiol 1713 to first trimester or term human placental minces caused a significant increase in the quantity of progesterone produced. Addition of an aromatase inhibitor, CGS 16949 A, or the estrogen receptor antagonist, ICI 182780, significantly inhibited progesterone production confirming the role of estradiol 1713 in the regulation of progesterone synthesis in human pla...