نتایج جستجو برای: radiation lethality
تعداد نتایج: 248735 فیلتر نتایج به سال:
Ionizing radiation is a major tool for cancer treatment. The response of eukaryotic cells to ionizing radiation includes apoptosis, a process which requires activation of multiple genes. We sought to determine whether radiation-induced gene expression plays a role in radiation-induced apoptosis. We found Apo2 ligand (Apo2L, also called TRAIL) mRNA induction following gamma-irradiation of Jurkat...
Abstract Background The intestine is particularly sensitive to moderate-high radiation dose and the development of gastrointestinal syndrome (GIS) leads rapid loss intestinal mucosal integrity, resulting in bacterial infiltration, sepsis that comprise patient survival. There an urgent need for effective therapeutic countermeasures. stromal vascular fraction (SVF) derived from adipose tissue eas...
Hybrid lethality is a type of reproductive isolation barrier observed in two developmental stages, hybrid embryos (hybrid seeds) and seedlings. has been reported many plant species limits distant hybridization breeding including interspecific intergeneric hybridization, which increases genetic diversity contributes to produce new germplasm for agricultural purposes. Recent studies have provided...
Abstract Isocitrate dehydrogenase (IDH) 1 or 2 mutant gliomas have unique metabolic characteristics and DNA damage response. Radiotherapy chemotherapy has been proven to be an effective treatment for IDH gliomas. A key mediator of response, Poly(ADP-ribose) (PAR) is regulated by opposing enzymes, poly(ADP-ribose) polymerases (PARPs) that synthesizes PAR through enzymatic polymerization nicotina...
BACKGROUND In light of the increased suicide rate in Korea, it has become important for researchers to examine the various factors associated with it. The purpose of this study is to compare and analyze the difference between suicide attempters and completers in terms of the suicide methods used and the lethality of these methods. In addition, we investigated certain demographic factors that ar...
We identified a synthetic lethality between PLK1 silencing and the expression of an oncogenic Epidermal Growth Factor Receptor, EGFRvIII. PLK1 promoted homologous recombination (HR), mitigating EGFRvIII induced oncogenic stress resulting from DNA damage accumulation. Accordingly, PLK1 inhibition enhanced the cytotoxic effects of the DNA damaging agent, temozolomide (TMZ). This effect was signif...
In recent years, cancer drug discovery has faced the challenging task of integrating the huge amount of information coming from the genomic studies with the need of developing highly selective target-based strategies within the context of tumour cells that experience massive genome instability. The combination between genetic and genomic technologies has been extremely useful and has contribute...
Radiation therapy plays an important role in the management of a wide range of cancers. Besides innovations in the physical application of radiation dose, radiation therapy is likely to benefit from novel approaches exploiting differences in radiation response between normal and tumor cells. While ionizing radiation induces a variety of DNA lesions, including base damages and single-strand brea...
These studies are primarily concerned with recovery from sublethal actinomycin D or radiation damage as measured by joint lethality of the two treatments separated by an interval of 1 hr to 4 days. In mice given actinomycin D and challenged with radiation, the high mortality attributable to joint treatment decreased steadily between the 6-hr and the 3-day challenge. On the other hand, in mice g...
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