نتایج جستجو برای: radiation lethality
تعداد نتایج: 248735 فیلتر نتایج به سال:
background: currently available radioprotectors are poorly tolerated in man and the general use of aminothiols is compromised by their side effects. this study was carried out to test and compare the radioprotective potential of cimetidine and famotidine against lethally gamma irradiated nmri mice. materials and methods: adult male nmri mice in groups of 10 were exposed to various doses of gamm...
Introduction: Radiation countermeasures are defined as use of an agent to minimize the deleterious effects of radiation therapy by administering the compound after the radiation exposure has occurred, regardless of toxicity. In spite of extensive study in this field, yet there is no suitable radioprotector introduced. In this study two naturally occurring antioxidants were stu...
In this paper we combine Japanese data on radiation exposure and cancer mortality with U.S. data on cancer incidence and lethality to estimate the effects of ionizing radiation on cancer incidence. The analysis is based on the mathematical relationship between the mortality rate and the incidence and lethality rates, as well as on statistical models that relate Japanese incidence rates to U.S. ...
We have recently developed a data-mining pipeline that comprehensively identifies cancer unique susceptibilities, following the concept of Synthetic Lethality (SL). The approach enables, for the first time, to identify and harness genome-scale SL-networks to accurately predict gene essentiality, drug response, and clinical prognosis in cancer.
With respect to radiation damage to humans, it is important to seek possible radioprotectants to modify the normal response of biological systems to radiation-induced toxicity or lethality. For this reasons, the search for less-toxic radiation radioprotectants has spurred interest in the development of different compounds. The radioprotective effects of citrus extract were investigated by using...
With respect to radiation damage to humans, it is important to seek possible radioprotectants to modify the normal response of biological systems to radiation-induced toxicity or lethality. For this reasons, the search for less-toxic radiation radioprotectants has spurred interest in the development of different compounds. The radioprotective effects of citrus extract were investigated by using...
Planning for and managing radiological terrorism incidents that involve the release of radionuclides from a dirty bomb requires considering the potential lifesaving impact of protective radionuclide decorporation countermeasures (e.g., lung lavage). Lung lavage therapy could prevent deaths via the pulmonary mode (which involves radiation pneumonitis and fibrosis) by reducing the radiation dose ...
WNT/β-catenin signalling is crucial for intestinal homoeostasis. The intestinal epithelium and stroma are the major source of WNT ligands but their origin and role in intestinal stem cell (ISC) and epithelial repair remains unknown. Macrophages are a major constituent of the intestinal stroma. Here, we analyse the role of macrophage-derived WNT in intestinal repair in mice by inhibiting their r...
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