Hyaluronic acid (HA) fillers in cosmetic medicine have been considered relatively safe, though fillers used in European countries and throughout the world are not necessarily approved by the Food and Drug Administration. As their use continues to expand worldwide, physicians in a wide range of medical specialties are authorized to perform HA injections, including general medicine practitioners ...

Olanzapine is an atypical antipsychotic widely used for the treatment of schizophrenia, which often causes serious adverse drug reactions. Currently, there are no clinical guidelines implementing pharmacogenetic information on olanzapine. Moreover, Dutch Pharmacogenomics Working Group (DPWG) states that CYP2D6 phenotype not related to olanzapine response or side effects. Thus, objective this ca...

Ipilimumab is an anti-CTLA-4 antibody that is approved for the treatment of metastatic malignant melanoma. Side-effects are mostly immune-mediated and in many cases the lack of specific symptoms leads to delayed diagnosis and treatment of adverse events. We present the case of a female patient who experienced an uncommon combination of adverse reactions while undergoing therapy with ipilimumab ...

Background Sublingual immunotherapy (SLIT) has been regarded as a viable alternative to subcutaneous immunotherapy (SCIT) since its introduction in 1986. Several studies have demonstrated the efficacy of SLIT. The safety profile of SLIT is superior to that of SCIT. No fatalities have been reported, and severe systemic reactions are rare. The rate of adverse event (AE) after SLIT is variable in ...

Correspondence to: Eduardo Dias de Andrade Department of Physiological Sciences Piracicaba Dental School Campinas State University Av. Limeira, 901 13414-903 Piracicaba-SP, Brazil E-mail: [email protected] Abstract Nonopioid analgesics are widely prescribed in dentistry. The first article of this series reviewed the mechanism of action of acetylsalicylic acid (aspirin), acetaminophen (par...

OBJECTIVE A reaction scale was used to assess noncardiac adverse reactions exhibited by nuclear medicine outpatients receiving intravenous dipyridamole for pharmacological stress testing. METHODS The study included 933 patients referred to 2 cardiac outpatient centers for assessment. All patients evaluated in this study were unable to perform treadmill stress testing and underwent pharmacolog...

OBJECTIVE To assess the efficacy and safety of low dose adrenaline injected subcutaneously to prevent acute adverse reactions to polyspecific antivenom serum in patients admitted to hospital after snake bite. DESIGN Prospective, double blind, randomised, placebo controlled trial. SETTING District general hospital in Sri Lanka. SUBJECTS 105 patients with signs of envenomation after snake b...

One hundred and thirty-two patients with rheumatoid arthritis treated with gold have been studied for possible associations between HLA DR antigens and different adverse reactions occurring during such therapy. Patients possessing HLA DR3 had a significantly greater frequency of side effects than patients lacking this antigen. It was particularly noticed that DR3 positive patients on gold treat...

Background: Although treatment guidelines for bipolar disorder in many countries commonly include lithium carbonate joint with sodium valproate, this combination is not effective for all patients. Moreover, some adverse reactions related to this treatment, neurotoxicity and interaction with other drugs justify and call for a new reviewing of the issue. Methods: Evidence base for the interaction...