نتایج جستجو برای: releasing hormone antagonist

تعداد نتایج: 213193  

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2000
M Schwahn H Schupke A Gasparic D Krone G Peter R Hempel T Kronbach M Locher W Jahn J Engel

Disposition and metabolism of cetrorelix was studied in intact and bile duct-cannulated rats and dogs after s.c. injection. An s.c. dose of 0.1 mg/kg [(14)C]cetrorelix was rapidly and completely absorbed in rats. T(max) in plasma and most tissues was at 2 h. Radioactivity at the injection site in rats declined to 10% by 24 h. The extent of (14)C absorption in rats calculated from excretion unti...

2017
Yoshiyuki Miyazawa Yoshitaka Sekine Takahiro Syuto Masashi Nomura Hidekazu Koike Hiroshi Matsui Yasuhiro Shibata Kazuto Ito Kazuhiro Suzuki

BACKGROUND Adrenal androgens play an important role in the development of castration-resistant prostate cancer therapeutics. The effect of gonadotropin-releasing hormone (GnRH) antagonists on adrenal androgens has not been studied sufficiently. We measured testicular and adrenal androgen levels in patients treated with a GnRH antagonist. METHODS This study included 47 patients with histologic...

Journal: :Cancer research 1990
B Szende G Srkalovic K Groot K Lapis A V Schally

Groups of 15 female Syrian golden hamsters with N-nitrosobis(2-oxopropyl)amine-induced pancreatic cancers were treated for 2 mo with microcapsules of the luteinizing hormone-releasing hormone (LH-RH) antagonist [Ac-D-Nal(2)1-D-Phe(4Cl)2-D-Pal(3)3,D-Cit6,D-Ala10] LH-RH (SB-75) releasing 8 micrograms/day or with the microcapsules of the LH-RH agonist D-tryptophan-6-luteinizing hormone-releasing h...

Journal: :journal of family and reproductive health 0
shamim pilehvari reproductive health research center, tehran university of medical sciences, tehran, iran ensieh shahrokh tehraninejad reproductive health research center, tehran university of medical sciences, tehran, iran batool hosseinrashidi reproductive health research center, tehran university of medical sciences, tehran, iran fatemeh keikhah reproductive health research center, tehran university of medical sciences, tehran, iran fedyeh haghollahi reproductive health research center, tehran university of medical sciences, tehran, iran elham aziminekoo reproductive health research center, tehran university of medical sciences, tehran, iran

objective: to compare the pregnancy outcomes achieved by in vitro fertilization (ivf) between minimal stimulation and conventional antagonist protocols in poor ovarian responders (pors). materials and methods: in this randomized controlled trial, 77 pors undergoing ivf were selected and divided into two groups. first group was the minimal stimulation group (n = 42) receiving 100 mg/day clomiphe...

2017
Fabio Lanfranco Matteo Baldi Giovanna Motta Marco Alessandro Minetto Filippa Marotta Valentina Gasco Ezio Ghigo

K. Ho (ed.), Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician, Contemporary Endocrinology, DOI 10.1007/978-1-60761-317-6_2, © Springer Science+Business Media, LLC 2011 Abstract Ghrelin, a 28 amino acid octanoylated peptide predominantly produced by the stomach, was discovered to be the natural ligand of the type 1a growth hormone (GH) secr...

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