HEPATIC OXYGEN METABOLISM 258 VULNERABILITY OF LIVER TO HYPOXIC AND ISCHEMIC INJURY 259 CELLULAR CHANGES IN HYPOXIA 259 ADENOSINE TRIPHOSPHATE DEPLETION AND HYPOXIC HEPATOCELLULAR NECROSIS 260 PROTECTION BY ACIDOTIC PH AGAINST HYPOXIC KILLING OF LIVER CELLS 261 THE PH PARADOX IN EARLY ISCHEMIA/REPERFUSION INJURY 262 THE MITOCHONDRIAL PERMEABILITY TRANSITION IN REPERFUSION INJURY 262 REACTIVE OX...

Hepatic ischemia-reperfusion injury (HIRI), which can severely impair liver function, has a potential relationship with reactive nitrogen species. Nitroxyl (HNO) been discovered for its involvements in some biological functions...

Purpose: Due to the severe clinical course and high socio-economic significance of acute kidney injury, issue methods for diagnosing treating this pathology is on agenda scientific community around world. One most specific biomarkers injury KIM-1. KIM-1 an apical transmembrane protein proximal renal tubule. Elevated levels in a model ischemia-reperfusion kidneys correlate with inflammation fibr...

A cute thrombotic occlusion of a coronary artery usually produces myocardial ischemia that can result in myocardial infarction if reperfusion is not restored. Reperfusion injury from reintroduction of blood and oxygen into the ischemic area at risk can result in additional myocyte cell death (1,2). Whereas early reperfusion therapy has been shown to reduce infarct size by decreasing ischemic in...

Objective: Previous studies reported that asafetida from Ferula assa-foetida Linn. species and its essential oil (AEO) have antioxidant effects. In the present study, the effect of AEO was evaluated on ischemic-reperfusion injury in isolated rat hearts. Materials and Methods: Forty-eight male Wistar rats were divided into 6 groups: 1) control group, 2) vehicle group, 3-5) AEO groups and, 6) car...

Objectives: Ischemia/reperfusion (I/R) injury is commonly seen in cardiovascular surgery, activates inflammation and causes renal damage. In this experimental study, we aimed to assess the effects of different doses (5 30 mg/kg) methylprednisolone (MP), which has anti-inflammatory effect, on ischemia/reperfusion injury. Methods: Thirty-two male Wistar albino rats were randomly divided into four...

MicroR-146 (miR-146) plays crucial roles in attenuating nerve injury during cerebral ischemia-reperfusion (I/R) injury. The purpose of this study was to investigate the neuroprotective effect miR-146 against I/R Rat model established using 4-vessel occlusion and reperfusion. In study, expression significantly decreased neurons rat compared sham group. addition, miR-146+/+ inflammatory cytokines...

Objective: It is generally agreed that most of the phenomena observed during brain ischemia and reperfusion can be explained by the damage to membrane structure. Oxidative stress is resulted in an imbalance between high consumption of oxygen and low levels of endogenous antioxidants. It is known that gallic acid (GA) is a strong antioxidant. The present study was carried out to evaluate the eff...

Introduction: Nucleobinding-2 (NUCB2) or nesfatin-1, a newly identified anorexigenic peptide, has antioxidant, anti-inflammatory, and anti-apoptotic properties. Brain ischemia-reperfusion induces irreversible damages, especially in the hippocampus area. However, the therapeutic effects of NUCB2 have not been well investigated in cerebral ischemia. This study was designed for the first time to i...