OBJECTIVES To compare extracellular and intracellular activities of telavancin (versus vancomycin) against Staphylococcus aureus (MSSA, MRSA, VISA and VRSA). METHODS Determination of cfu changes (3-24 h) in culture medium and in macrophages at concentrations ranging from 0.01 to 1000x MIC. RESULTS Extracellularly, telavancin displayed a fast, concentration-dependent bactericidal activity ag...

the objective of this study was to determine the occurrence of antimicrobial resistance among staphylococcus aureus and to estimate the presence of methicillin-resistance in s. aureus (mrsa) isolates obtained by culture and polymerase chain reaction (pcr) methods. for this purposes, 100 iranian white and feta cheese samples collected from different suppliers were initially evaluated for the occ...

introduction: methicillin-resistant staphylococcus aureus (mrsa) can cause serious and life-threatening hospital- and community-acquired infections. colonized and infected patients represent the most important reservoir of mrsa in health care facilities. therefore, in this study, mrsa isolates collected from shohada hospital in tabriz were evaluated for the frequency of meca gene and their anti...

b ackground: methicillin-resistant staphylococcus aureus (mrsa) is the one of most commonly isolated organisms from clinical samples which can cause life- threatening infections. the emergence and spread of antibiotic resistance makes the treatment of these infections more complicated. in this study, we aimed to determine  the  patterns  of  antibiotic  resistance  among  mrsa  isolates  from t...

background and objectives: due to the importance of finding of new antibacterial agents, the antibacterial properties of prosopis cineraria aerial parts were investigated using a bioassay guided fractionation scheme. materials and methods: the organic extract was prepared via maceration in methanol, followed by the fractionation using n-hexane and ethyl acetate. the mics of fractions were deter...

background: staphylococcus aureus has been recognized as a major human pathogen and is the major cause of nosocomial infections. gamma-toxin, leukocidin and other bi-component toxins are a family of proteins encoded by the hlg and luk-pv, respectively. panton-valentine leukocidin (pvl) is an example of these toxins and causes leukocyte destruction and tissue necrosis. the aim of this study was ...

background methicillin-resistant staphylococcus aureus (mrsa) remains a significant public health problem and treatment challenge. objectives this study was conducted to determine the frequency, molecular types, and drug resistance of s. aureus isolated from nasal carriers in two teaching hospitals (hajar and kashani) in shahrekord, southwestern iran. methods in this cross-sectional study, 262 ...

conclusions regarding clinical and laboratory standards institute (clsi) definition for vancomycin susceptibility (mic < 2 μg/ml), it seems that vancomycin may not be considered as the best antibiotic in order to treat heteroresistant vancomycin intermediate s. aureus (hvisa) and vancomycin sensitive s. aureus (vssa) infections, and a new breakpoint for vancomycin and alternative antibiotics sh...