in the present study, we describe a subcutaneous mass between the left flank and hip in a 2-year-old male great dane dog. histopathologically, cells appeared to be spindle shaped around a central capillary together with a fingerprint pattern. immunohistochemical analysis presented that the neoplastic cells expressed vimentin, but did not stain for s-100 protein. on the basis of histopathology a...

Objective(s): To explore whether endoplasmic reticulum (ER) stress regulates inflammation in adipose tissue of obese rats via TLR4 signaling. Materials and Methods: Sprague Dawley rats were randomly divided into four groups, and body weight, food intake, and free fatty acids (FFA) were measured. Real-time PCR and Western blot were used to determine mRNA or protein expression of TLR4, TRAF6, IKK...

after the classification of the flag-transitive linear spaces, the attention has been turned to line-transitive linear spaces. in this article, we present a partial classification of the finite linear spaces $mathcal s$ on which an almost simple group $g$ with the socle $g_2(q)$ acts line-transitively.

AIMS To examine how accurately immunohistochemical markers discriminate between pancreatobiliary and intestinal-type adenocarcinomas in the pancreatic head and to explore the prognostic importance of these markers among each of these histological types. METHODS AND RESULTS Histopathological features of 114 consecutively resected adenocarcinomas of pancreatobiliary (n = 67) and intestinal (n =...

objective(s) definite diagnosis of hirschsprung’s disease (hd) is based on histopathological study, but there are limitations associated with standard histology and histochemistry in this regard. the aim of this study was to investigate calretinin immunostaining patterns in both ganglionic and aganglionic hd intestinal specimens and to compare them with control specimens. materials and methods ...

inverted follicular keratosis (ifk) a benign tumor of skin appendages which is mostly presented as a solitary nodule with keratotic or scaling surface on the face of a middle aged or old patients but it can develop in other parts of the body. different studies have lead to development of different theories about the role of human papillomavirus (hpv) in this kind of skin tumor. the purpose of t...

background and objective: histological grading has prognostic and therapeutic implications in meningioma. however, histological criteria are sometimes not fulfilled to predict the biological behavior of meningiomas. p63 gene is a novel p53 family member, known as tumor suppressor factor, with multiple isoforms and shows high expression in many normal and neoplastic human tissues. in this study,...

Objective(s): The aim of this study was to observe the impact of sirolimus on proteinuria in streptozotocin (STZ) induced diabetic rats. Materials and Methods: Rats were given a single injection of STZ to induce diabetic rat model. Rats’ 24 hr urine was collected to test, urinary and the kidney tissues were harvested at the 8th and 20th weeks, respectively. Podocyte morphological changes were e...

Objective(s):To investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats. Materials and Methods:Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). MCAO/R model was established by Longa’s method, and reperfusion was allowed after 2 hr occlusion. Mild hypo...