In clinical research, comparisons of the results from experimental and control groups are often encountered. The two-sample t-test (also called independent samples t-test) and the paired t-test are probably the most widely used tests in statistics for the comparison of mean values between two samples. However, confusion exists with regard to the use of the two test methods, resulting in their i...

Aims / Objectives: To introduce a statistical test, which is mixture of the one-sample t-test and Wilcoxon signed-rank test depends on sample kurtosis, using data from symmetric univariate distribution with finite variance.
 Study Approach: Computer simulation coverage probabilities power calculations either or based software R.
 Methodology: Data are generated differing sizes Normal,...

This paper compares the type I error and power of the one- and two-sample t-tests, and the one- and two-sample permutation tests for detecting differences in gene expression between two microarray samples with replicates using Monte Carlo simulations. When data are generated from a normal distribution, type I errors and powers of the one-sample parametric t-test and one-sample permutation test ...