OBJECTIVE To develop topical gel preparations of astemizole and terfenadine and to investigate the actions of the gels on the healing of incision and excision wounds in male albino rats. MATERIALS AND METHODS Gels containing 1% astemizole, with varying concentrations of carbopol 934 (polymer), were prepared. Similarly, 1% terfenadine gels were made. The formulations were evaluated for release...

scar endometriosis is a rare form of extra-pelvic endometriosis that can occur after surgery involving the uterus. direct mechanical implantation seems to be the most conceivable theory for scar endometriosis. patient usually presents with lump and pain at surgical site. often the diagnosis of endometriosis is not suggested until histology has been performed. we hereby present a case of scar en...

This article reports on the histologic findings from a larger study that was designed to investigate whether the attachment of scar tissue to underlying bone, which is normally found after palatal surgery, can be prevented by using biodegradable poly-(L-lactic) acid membranes. Von Langenbeck's procedure was simulated in 12-week-old beagle dogs without clefts. In one group normal wound healing w...

The purpose of this study was to evaluate artificial dermis with the simultaneous addition of autologous epithelial cells for oral lesion defect reconstruction. Surgical wounds reconstructed with artificial dermis plus scraped epithelial cells were evaluated in 5 patients with oral benign lesions or squamous cell carcinoma. Clinical follow-up indices included scar formation and tissue surface t...

Scar formation is a frequently occurring unwanted result of healing of a skin wound. The mechanisms causing scar formation are not fully understood, although many studies have attempted to unravel this issue. Most of these studies were performed in animals or in in vitro models, but both have major drawbacks. In the present study we aimed to develop a representative model in which the human wou...

Hypertrophic scars (HTS), the excessive deposition of scar tissue by fibroblasts, is one of the most common skin disorders. Fibroblasts derived from surgical scar tissue produce high levels of α-smooth muscle actin (α-SMA) and transforming growth factor-β1 (TGF-β1). However, the molecular mechanisms for this phenomenon is poorly understood. Thus, the purpose of this study was to evaluate the mo...

Porcine thermal burns have been widely employed for examining the beneficial effects of novel burn treatments prior to clinical application and for understanding the mechanisms of burn wound healing 1, 2. The advantages of these porcine burns over other animal burns are well described by others, such as the well described close resemblance to human skin in structure and in wound healing. Import...

Plantain banana (M. sapientum var. paradisiaca, MS) has been shown to possess ulcer healing activity. The present work with plantain banana was undertaken with the premise that the drug promoting ulcer healing could have effect on wound healing also. Wound healing activity of MS was studied in terms of (i) percent wound contraction, epithelization period and scar area; (ii) wound breaking stren...

in this paper, we establish and prove the existence of best proximity points for multivalued cyclic $f$- contraction mappings in complete metric spaces. our results improve and extend various results in literature.

recently, choudhury and metiya [fixed points of weak contractions in cone metric spaces, nonlinear analysis 72 (2010) 1589-1593] proved some fixed point theorems for weak contractions in cone metric spaces. weak contractions are generalizations of the banach's contraction mapping, which have been studied by several authors. in this paper, we introduce the notion of $f$-weak contractions and als...