linear and cord-like burn scar contractures are commonly treated by severing the scar in a transverse direction and skin grafting or performing z-plasties. however, skin grafts may result in suboptimal take and contract gradually and the z-plasty requires undermining flaps in scarred skin which may lead to the distal tip necrosis. in this article the authors present their experience with multip...

Excessive contraction of hypertrophic scar and subsequent contracture formation are a formidable problem after thermal injury. A comparison between fibroblasts from hypertrophic scar and normal skin was made with the use of fibroblast-populated collagen lattices as a measure of cellular generated contractile forces. Hypertrophic scar and normal skin fibroblasts were mixed with soluble tendon co...

Introduction Healing of deep skin wounds in the adult mammal takes place by the processes of wound contraction and scar formation. There is evidence that scar formation is secondary to contraction. Efforts to block scar formation can therefore benefit from strategies for blocking contraction. In this review we provide a semiquantitative description of healing outcomes based on the wound closure...

Abnormal wound healing is likely to induce scar formation, leading to dysfunction, deformity, and psychological trauma in burn patients. Despite the advancement of medical care treatment, scar contracture in burn patients remains a challenge. Myofibroblasts play a key role in scar contracture. It has been demonstrated that myofibroblasts, as well as inflammatory cells, fibroblasts, endothelial ...

A scar is the result of wound healing, modified by the nature, site, and orientation of the wound, and the method and skill of its repair. In the healing of an unrepaired wound three processes influence the final scar: wound contraction; epithelial migration; and scar maturation (and its anomalies, hypertrophy and keloid, contracture, and stretching). Surgical repair of the wound bypasses the f...

BACKGROUND The aim of the study was to perform a feature tracking analysis on cine magnetic resonance (MR) images to elucidate if functional measurements of the motion of the left ventricular wall may detect scar defined with gadolinium enhanced MR.Myocardial contraction can be measured in terms of the velocity, displacement and local deformation (strain) of a particular myocardial segment. Con...

UNLABELLED Burn injuries in the United States account for over one million hospital admissions per year, with treatment estimated at four billion dollars. Of severe burn patients, 30-90% will develop hypertrophic scars (HSc). In this study, we evaluate the impact of an elastomeric, randomly-oriented biostable polyurethane (PU) scaffold on HSc-related outcomes. In vitro, fibroblast-seeded PU sca...

Oral wounds heal faster and with better scar quality than skin wounds. Deep skin wounds where adipose tissue is exposed, have a greater risk of forming hypertrophic scars. Differences in wound healing and final scar quality might be related to differences in mesenchymal stromal cells (MSC) and their ability to respond to intrinsic (autocrine) and extrinsic signals, such as human salivary histat...

Hypertrophic scar (HSc) contraction following burn injury causes contractures. Contractures are painful and disfiguring. Current therapies are marginally effective. To study pathogenesis and develop new therapies, a murine model is needed. We have created a validated immune-competent murine HSc model. A third-degree burn was created on dorsum of C57BL/6 mice. Three days postburn, tissue was exc...