Abstract The human ATP-binding cassette B5 (ABCB5) transporter, a member of the ABC transporter superfamily, is linked to chemoresistance in tumour cells by drug effluxion. However, little known about its structure and drug-binding sites. In this study, we generated an atomistic model full-length ABCB5 with highest quality using X-ray crystal mouse ABCB1 (Pgp1), close homologue well-studied fam...

objective(s): organic cation transporter 3 (oct3) as a high-capacity transporter contribute to the metabolism of metformin. the present study was conducted to determine the genotype frequencies of the variant oct3-1233g>a (rs2292334) in patients with newly diagnosed type 2 diabetes (t2d) and its relationship with response to metformin. materials and methods: this study included 150 patients wit...

conclusions it can be concluded that the nettle extract can reduce blood glucose levels in diabetic mice, at least partly, by influencing the glut2 gene expression in mice liver. results the results showed that the nettle extract significantly decreased high levels of blood glucose (p < 0.001). the nettle extract also had a preventive effect on decrease in body weight. in addition, the results ...

BACKGROUND The increased susceptibility for developing alcohol dependence seen in offspring from families with alcohol dependence may be related to structural and functional differences in brain circuits that influence emotional processing. Early childhood environment, genetic variation in the serotonin transporter-linked polymorphic region (5-HTTLPR) of the SLCA4 gene and allelic variation in ...

The high-payload transporter is a key part of the multipurpose deployer, which important for realizing remote handling tokamaks. This paper presents an analysis joint between and design test platform. kinematic, structural, load characteristics main joints heavy-duty manipulator were analyzed according to peculiarity high precision, large length, heavy transporter. Joint No. 4 (J4) was determin...

background attitude and knowledge of the different groups of society play an important role in facilitating living conditions and meeting the needs of the disabled elderly. objectives the current study aimed to evaluate the attitude and knowledge of medical sciences students toward the disabled elderly from different angles. patients and methods ninety students from semnan university of medical...

ZIP (Zinc-regulated transporter, Iron-regulated transporter-like Protein, ZIP) plays an important role in uptake or transport Zn Fe plants. So studying ZIPs plant can help to elucidate the molecular mechanism for and transportation. Herein, we have cloned a novel transporter gene NoZIP3 from Nasturtium officinale root using rapid-amplification of cDNA ends (RACE) method, evaluated its function ...

Orally administered small molecules may have important therapeutic potential in treating COVID-19 disease. The recently developed antiviral agents, Molnupiravir and Nirmatrelvir, been reported to be efficient treatments, with only moderate side effects, especially when applied the early phases of this However, drug–drug drug–transporter interactions already noted by drug development companies a...