Most excellent object-oriented frameworks are still the product of a more or less chaotic development process, typically carried out in the realm of research-like settings. Overall, flexibility has to be injected into a framework in appropriate doses1. Framework adaptation takes place at points of predefined refinement that we call hot spots. As the quality of a framework depends directly on th...

In this research and development project we are exploring a new approach of mobile web and location-based services (LBS) for communication / collaboration which is based on a physical hot spot serving as an accumulation point; a hub for thematic and social collaboration. Different actors can consult, publish or exchange information in relation with the location materialized by the hot spot. Thi...

(0.8 mg of DT at 400 g/cm) has been derived from the energy balance of an hypothetical power plant [2]. Secondly, self-consistent 2D radiation hydrodynamic simulations with MULTI [3, 4] allows us to define and optimize a HIB-driven hohlraum target, as well as to determine the minimum PB energy ( 33 kJ) needed to ignite the asymmetrically compressed fuel. Thermonuclear ignition and burn is now i...

The main function of a wireless sensor network is to sense the outside environment and report the data to a processing center. Therefore, both sensing and communication roles should be considered for a sensor network. Except for the mobility aspect, sensor networks inherit almost all properties of ad hoc networks. Therefore, sensor nodes are supposed to report data to a common sink instead of s...

A recent report from the Milagro collaboration included an all-sky map created using one year of data from Milagro (peak sensitivity at 3-4 TeV for Crab-like spectra). This map included an unidentified excess that was brighter than the Crab and was the second brightest spot on the map. The hot spot was within the error box of the EGRET unidentified source 3EG J0520+2556. No strong and steady em...

Innervation of the skeletal muscle involves local signaling, leading to acetylcholine receptor (AChR) clustering, and global signaling, manifested by the dispersal of preexisting AChR clusters (hot spots). Receptor tyrosine kinase (RTK) activation has been shown to mediate AChR clustering. In this study, the role of tyrosine phosphatase (PTPase) in the dispersal of hot spots was examined. Hot s...

BACKGROUND Staging of melanoma includes quantification of a proliferation index, i.e., presumed melanocytic mitoses of H&E stains are counted manually in hot spots. Yet, its reproducibility and prognostic impact increases by immunohistochemical dual staining for phosphohistone H3 (PHH3) and MART1, which also may enable fully automated quantification by image analysis. To ensure manageable workl...

We report Chandra X-ray Observatory and 1.4 GHz Australian Long Baseline Array (LBA) observations of the radio galaxy PKS 2153–69 and its environment. The Chandra image reveals a roughly spherical halo of hot gas extending out to 30 kpc around PKS 2153–69. Two depressions in the surface brightness of the X-ray halo correspond to the large scale radio lobes, and interpreting these as cavities in...

We report the detection of variable emission from Sgr A* in almost all wavelength bands (i.e. centimeter, millimeter, submillimeter, near-IR and X-rays) during a multi-wavelength observing campaign. Three new moderate flares are detected simultaneously in both near-IR and X-ray bands. The ratio of X-ray to near-IR flux in the flares is consistent with inverse Compton scattering of near-IR photo...