The interaction of long-chain fatty acids with cells is important for their uptake and metabolism, as well as their involvement in signalling processes. The majority of long-chain fatty acids circulating in plasma exist as complexes with serum albumin. Thus an understanding of the involvement of serum albumin in these processes is vitally important. The effect of serum albumin on the uptake of ...

background: the modern dairy cows, due to intensive selection for higher milk production during past decades, have become more resistant to insulin. accompanied with dmi depression in per parturient dairy cow, insulin resistance may lead to a massive release of non-esterified fatty acids (nefa) to bloodstream which might act as a start point for development of other diseases. objectives: the pu...

Dyslipidemia is an important risk factor for cardiovascular disease (CVD) and an important cause of death in adults. Long-term follow-up studies have demonstrated that dietary fat consumption in children and adolescent is one of these risk factors of dyslipidemia in adulthood. The purpose of the current study was to assess the dietary fat intake of Iranian adolescents and their relationship wit...

Here a useful gas chromatography mass spectrometry method for determining levels of fatty acids in the maternal serum was developed and validated. Forty-five mixed standards of fatty acids methyl ester of more geometrical isomers and biological significance were separated on a capillary column with higher polarity and thinner film thickness. The total run time was approximate 36 min. Twenty ser...

BACKGROUND There is some evidence from experimental studies that long-chain n-3 and n-6 fatty acids may be able to modify early skin carcinogenesis, but whether this applies in the general population is not known. METHODS We investigated associations between serum polyunsaturated fatty acid concentrations and p53 expression in normal skin, as a biomarker of early UV-induced carcinogenesis, in...

VEGETABLE oils lower the serum cholesterol level in man, and this effect is probably due to their content of polyunsaturated fatty acids, as has been demonstrated by Kinsell and co-workers, Ahrens and co-workers, Malmros and Wigand, and others. Separation of total fatty acids in serum has been performed in normal subjects and patients with demonstrated atherosclerosis by Hammond and Lundberg, S...

A stable essential fatty acid-deficient cell type, known as HepG2-EFD, was derived from the lipoprotein-producing human hepatoma cell line HepG2. These cells are particularly useful for quantitative studies involving essential fatty acids (n-6 and n-3 fatty acids) in secreted lipoproteins. Radiolabeled essential fatty acids can be delivered to these cells without altering the specific activity ...

The presence of elevated glucose concentrations in diabetes is a metabolic change that leads to an increase in the amount of non-enzymatic glycation that occurs for serum proteins. One protein that is affected by this process is the main serum protein, human serum albumin (HSA), which is also an important carrier agent for many drugs and fatty acids in the circulatory system. Sulfonylureas drug...