Thrombotic thrombocytopenic purpura (TTP) is a type of microangiopathy, which characterized by the formation small blood clots in vessels, leading to organ damage and low platelet count. In sickle cell disease (SCD), TTP can occur due activation coagulation system endothelial cells lining vessels. The importance SCD lies its potential cause severe life-threatening complications, including strok...

A hybrid erythrocyte model for membrane studies in sickle cell disease has been developed. The model consists of normal red cell membranes containing hemoglobin S and sickle cell membranes containing hemoglobin A. In hybrids, complete hemoglobin exchange has been achieved together with restoration of low membrane permeability to potassium. Normal membranes containing HbS sickle upon deoxygenati...

Editorial left ventricular dysfunction in sickle cell disease: the value of an electrocardiographic marker of increased risk of arrhythmia Sickle cell disease is one of the most prevalent genetic diseases worldwide; affecting 1/400 individuals of African descent as well as people of Arab, Indian and Hispanic descents. Abnormalities of cardiovascular function have increasingly been documented in...

recently, cell therapy has sparked a revolution in ischemic heart disease that will in the future help clinicians to cure patients. earlier investigations in animal models and clinical trials have suggested that positive paracrine effects such as neoangiogenesis and anti-apoptotic can improve myocardial function. in this regard the royan cell therapy center designed a few trials in collaboratio...

on determinations of hemoglobin A1c by an immunoassay method. Diabetes Care 1998;21:983–6. 6. Roberts WL, Chiasera JM, Ward-Cook KM. Glycohemoglobin results in samples with hemoglobin C or S trait: a comparison of four test systems. Clin Chem 1999;45:906–9. 7. Eckman JR. The Sickle Cell Foundation of Georgia, Inc. The Sickle Cell Information Center. http://www.emory.edu/PEDS/SICKLE/hemoglb.htm ...

Liver involvement in patients with sickle cell anemia/trait includes a wide range of alterations, from mild liver function test abnormalities to cirrhosis and acute liver failure. Approximately 15-30% of patients with sickle cell anemia present cirrhosis at autopsy. The pathogenesis of cirrhosis is usually related to chronic hepatitis B or C infection or to iron overload resulting from the many...

Patients with sickle cell anaemia have an increased susceptibility to bacterial infections Previous reports of false-negative nitro blue tetrazolium (NBT) tests in the presence of bacteria infection and of a faulty phagocytic response following stimulation in vitro have suggested the possibility of polymorphonuclear dysfunction in certain patients with sickle cell anaemia. In the present study ...

Micropipette aspiration tests on single erythrocytes have previously shown that the static rigidity (membrane shear modulus) of oxygenated sickle cells increased with increasing hemoglobin concentration, whereas the rigidity of normal cells was independent of hemoglobin concentration. Moreover, it was observed that after mechanical extension, sickle cells exhibited persistent deformation more f...

INTRODUCTION The aim of this study was aim to evaluate cardiac function by means of echocardiography in patients with sickle cell anemia. METHODS This was a case control study that evaluated a total of 44 patients with sickle cell anemia, who were on regular follow up, and 44 age/sex-matched normal healthy control subjects. M-mode, two-dimensional, Doppler and pulse tissue-Doppler echocardiog...