The Ski oncoprotein has been found to bind non-specifically to DNA in association with unindentified nuclear factors. In addition, Ski has been shown to activate transcription of muscle-specific and viral promoters/enhancers. The present study was undertaken to identify Ski's DNA binding and transcriptional activation partners by identifying specific DNA binding sites. We used nuclear extracts ...

The purpose of this study was to investigate Paralympic coaches' perceptions of team cohesion. Seven head coaches of summer and winter Canadian Paralympic sport teams participated in the study. Four participants coached individual sports and 3 coached team sports. Data were collected using semistructured interviews and analyzed using thematic analysis. The results addressed the coaches' percept...

Abstract. The player of squash has a choice between two options when his/her opponent changes the score from 8:7 to 8:8. The player to receive has to decide whether to play until 9th or until 10th point. We observe in this paper that the score of the squash game can be modelled as a Markov chain. Thus using standard techniques of Markov processes, we can derive the optimal strategy for the squa...

Cardiac myofibroblasts are key players in chronic remodeling of the cardiac extracellular matrix, which is mediated in part by elevated transforming growth factor-β₁ (TGF-β₁). The c-Ski proto-oncoprotein has been shown to modify TGF-β₁ post-receptor signaling through receptor-activated Smads (R-Smads); however, little is known about how c-Ski regulates fibroblast phenotype and function. We soug...

In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed "RU-SKI") class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b),...

The c-ski protooncogene encodes a transcription factor that binds DNA only in association with other proteins. To identify co-binding proteins, we performed a yeast two-hybrid screen. The results of the screen and subsequent co-immunoprecipitation studies identified Smad2 and Smad3, two transcriptional activators that mediate the type beta transforming growth factor (TGF-beta) response, as Ski-...

In ski jumping low body weight development resulted in some serious underweight problems and therefore International Ski Federation (FIS) decided to solve the problem by relating maximum ski length to Body Mass Index (BMI). The present study examined the current relationship between body weight (BMI), ski length and performance (jumping distance) in ski jumping. The computer simulation showed t...

‘New media’ such as social media content-sharing apps and podcasting platforms have democratised mass by enabling producers to disseminate content that is otherwise of limited interest mainstream broadcast media, though may be great members nuanced worlds. Producers bespoke sport-related recently harnessed new create commercially viable outlets. We contend the can contribute authentication plac...

Recent technological developments have led to the production of inexpensive, non-invasive, miniature magneto-inertial sensors, ideal for obtaining sport performance measures during training or competition. This systematic review evaluates current evidence and the future potential of their use in sport performance evaluation. Articles published in English (April 2017) were searched in Web-of-Sci...