IMPORTANCE >50% of patients with new-onset type 1 diabetes (T1D) do not enter partial clinical remission (PCR); early identification of these patients may improve initial glycemic control and reduce long-term complications. AIM To determine whether routinely obtainable clinical parameters predict non-remission in children and adolescents with new-onset T1D. SUBJECTS AND METHODS Data on remi...

We integrated visual and quantitative methods for analyzing the stability of respiration using four methods: phase space diagrams, Fourier spectra, Poincaré maps, and Lyapunov exponents. Respiratory patterns of 139 patients were grouped based on the combination of the regularity of amplitude, period, and baseline positions. Visual grading was done by inspecting the shape of diagram and classifi...

Atenolol is a selective β1 receptor antagonist that is available as a racemic mixture. The objective of this study was to compare the pharmacokinetics and evaluate the bioequivalence of 50 mg atenolol test and reference formulations in 24 healthy Korean male volunteers.This study was a single-dose, randomized, open-label, 2 period crossover study. 24 healthy Korean male volunteers randomly rece...

The authors report on the variability in the integrated quantity of free (unbound) plasma cisplatin (area under curve of plasma concentration versus time, AUC). The AUC was measured in 19 patients receiving cisplatin doses proportional to body surface areas (BSA), 30 mg/m2 over 1 hour. The relative standard deviation (RSD, population standard deviation divided by mean value) for the maximum fre...

Ellipse fitting for iris boundary is an important step in eye gaze estimation and iris recognition applications. In most of the proposed algorithms only the edge image is used for ellipse fitting. In these algorithms, the undesired edges may lead to erroneous iris ellipse. In this paper, we propose a novel algorithm to ellipse fitting for iris boundary which uses gray and edge images simultaneo...

BACKGROUND The Fonseca Anamnestic Index is a questionnaire used to classify individuals with temporomandibular disorders. Previous studies have shown that the Fonseca Anamnestic Index provides a multidimensional measurement of the temporomandibular disorders construct and that the main dimension presents a good fit to the model according to the item response theory. OBJECTIVE To evaluate the ...

1-type and biharmonic curves by using laplace operator in lorentzian 3-space arestudied and some theorems and characterizations are given for these curves.

OBJECTIVE With the coming of the laparoscopy, multiple surgical techniques have been developed that have revolutionized the urological practice. The laparoscopic pyeloplasty has been one of the techniques most developed. However, there are very few training models that permit the surgeon to decrease the learning curve. An animal model of training for the laparoscopic pyeloplasty technique is de...

OBJECTIVE An awareness of the repeatability of biological measures is required to properly design and calculate sample sizes for longitudinal interventional studies. We investigated the day-to-day repeatability of measures of systemic microvascular reactivity using laser Doppler perfusion monitoring. METHODS We performed laser Doppler perfusion monitoring in combination with skin iontophoresi...