In budding yeast cells, nutrient repletion induces rapid exit from quiescence and entry into a round of growth and division. The G1 cyclin CLN3 is one of the earliest genes activated in response to nutrient repletion. Subsequent to its activation, hundreds of cell-cycle genes can then be expressed, including the cyclins CLN1/2 and CLB5/6. Although much is known regarding how CLN3 functions to a...

Hereditary folate malabsorption is a rare inborn error of metabolism due to mutations in the proton-coupled folate transporter (PCFT). Clinical presentation of PCFT deficiency may mimic severe combined immune deficiency (SCID). We report a 4-month-old female who presented with failure to thrive, normocytic anemia, Pneumocystis jirovecii pneumonia and systemic cytomegalovirus infection. Immunolo...

OBJECTIVES Recovery is a crucial factor for soccer players, which nutritional intake essential. The purpose of this study to introduce 4R nutrition strategies optimized recovery players and provide practical guidelines.METHODS A literature review was conducted through web searches on PubMed, Web Science, Wiley Online Library, using keywords such as “soccer,” “recovery,” “nutrition."RESULTS For ...

Severe hypernatremia is defined as serum sodium levels above 152 mEq/L, with a mortality rate ≥60%. 85-year-old gentleman was brought to the emergency room with altered level of consciousness after refusing to eat for a week at a skilled nursing facility. On admission patient was nonverbal with stable vital signs and was responsive only to painful stimuli. Laboratory evaluation was significant ...

A credible theory of intelligence must provide a satisfactory account of the wide spectrum of learning abilities displayed by humans and some other animals. One of the most impressive of these is skill acquisition—the ability to create new skills, refine them through practice, and apply them in new task contexts. This ability to retain and refine solutions to important subproblems and then empl...

The simultaneous consideration of various notions (practice, procedure, prescribed task, effective task, task space, task search, task, method, activity) shows that the task accomplishment cannot be discussed at a general level, as classical approaches do. Rather, this paper points out the importance to distinguish the task definition and the task realization because the former is mainly static...

The notion of a compensation is widely used in advanced transaction models as means of recovery from a failure. Similar concepts are adopted for providing “transaction-like” behavior for long business processes supported by workflows technology. Generally, designing a compensating task in the context of a workflow process is a non-trivial job. In fact, not every task is compensatable. This work...