objective(s) there are some reports that the teratogenic effects of cyclophosphamide (cpa) can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. echinacea purpurea extract is antioxidative and immunomodulator drug. mesna (sodium 2-mercaptoethane sulfonate) is used for decreasing side effects of cpa, especially hemorrhagic cystitis. in this study, we...

objective: safety of lippia citriodora, as a herbal remedy, in pregnancy has not yet been evaluated. this study aimed to identify the effect of l. citriodora aqueous extract on pregnancy outcome in mice. materials and methods: timed-pregnant mice received doses of 0.5 g/kg/day l. citriodora aqueous extract or the vehicle control during organogenesis, intraperitoneally. maternal body weights wer...

Pregnant Wistar Albino rats were injected intraperitoneally with the thyroid stimulating hormone (TSH), obtained from several different suppliers, and with the dye trypan blue. Twenty USP units of TSH were injected on days 7 to 10 of pregnancy, one quarter of the total dose each day. Trypan blue was injected as a single subteratogenic dose (0.6 mg/100 gm maternal body weight) on day 8. Autopsy ...

I have read with interest Dr. D.T. Janerich's article (April 23, p. 1058) confirming the teratological effect of hormonal pregnancy tests and other exogenous sex hormone preparations in relation to congenital heart diseases. The discovery of the teratological effect of hormonal pregnancy tests emerged from my studies into central nervous system malformations in 1967. In this and in further pu...

Enamel matrix derivative Emdogain (EMD) is widely used in periodontal treatment in spite of the fact that its effect on the developing embryo has not been elucidated. The aim of this study was to investigate the teratogenic effect of EMD on the rat embryo neural crest cells. The neural crest is a unique population of cells that migrates from the dorsal neural tube along defined pathways and pro...

The effect of rapeseed oil methyl ether (RME) on cladocerans (water flea Daphnia magna Straus) and fish embryos prolarvae (round goby Neogobius melanostomus (Pallas)) is investigated. It has been determined that, with the increase RME content in water, decrease survival rate, fecundity, abundance, biomass population observed, as well rate round fry linear weight growth fry. did not produce any ...