BACKGROUND HCV infection and transfusional iron overload in Thalassemic patients may result in liver disease. HCV treatment in Thalassemia has raised safety concerns. AIM Estimate effectiveness and tolerability of interferon-based therapy in HCV-infected Thalassemic patients. MATERIAL AND METHODS Over a 12-year period, consecutive patients with β Thalassemia major (TM) and chronic hepatitis...

BACKGROUND Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of hemoglobin. This disorder results in excessive destruction of red blood cells, and there is no effective treatment. Patients require lifelong blood transfusion, usually started within 6 to 12 months of birth of patient, which on other hand has its own complications. It...

AIMS The hereditary β-thalassemia major condition requires regular lifelong blood transfusions. Transfusion-related iron overloading has been associated with the onset of cardiovascular complications, including cardiac dysfunction and vascular anomalies. By using an untransfused murine model of β-thalassemia major, we tested the hypothesis that vascular endothelial dysfunction, alterations of a...

BACKGROUND Thalassemic disorders are the most prevalent monogenic hereditary diseases around the world caused by decreased and altered synthesis or agenesis in one or more globin chains. Families who have a child with thalassemia major face a myriad of significant problems. Hormozgan province ranks second with thalassemic patients in Iran. Therefore, current research is aimed to analyze the rep...

an f2 japanese quail population was developed by crossing two strains (wild and white) to map quantitative trait loci (qtl) for performance and carcass traits. a total of 472 f2 birds were reared and slaughtered at 42 days of age. performance and carcass traits were measured on all of the f2 individuals. parental (p0), f1 and f2 individuals were genotyped with 3 microsatellites from quail chrom...

Abstract Background The purpose of this study was to assess the prevalence of major depressive and anxiety disorders in hemophilic and major beta thalassemic patients related to education of their mothers as a family’s agent. Materials and Methods A case-control study was performed on 34 major beta thalassemic patients. For each patient the control group was selected and matched (with age a...