objective: the two most frequent hypochromic microcytic anemias are β- thalassemia minor (btm) and iron deficiency anemia (ida). several discrimination indices have been proposed to quickly discriminate these similar entities via parameters obtained from automated blood count analyzers. the aim of this study to evaluate the diagnostic reliability of ten discrimination indices in the differentia...

This paper presents the use of a genetic programming (GP) system called STROGANOFF and a multilayer perceptron for thalassemic patient classification. The interested problem covers the test samples from normal subjects and that from different types of thalassemic patient and thalassemic trait. The features, which are the characteristics of red blood cell, Thalassemic Patient Classification Usin...

We report the case of a 13-year-old male patient with beta-thalassemic trait who presented for a colic pain. An ultrasound of the abdomen revealed absence of the right kidney with a complex hypoechogenic pelvic mass causing mild pressure on the posterior bladder wall. Urography showed hypertrophy of the left kidney with moderate ureteral enlargement of the distal third due to an insertion defec...

The level of Hb C in the erythrocytes of individuals with Hb C trait decreases significantly in the presence of coexisting a-thalassemia. This relationship may result from the higher affinity of 9A than c for limiting amounts of a-globin during hemoglobin assembly. This mechanism would predict that the 1 A and synthetic capacity in a-thalassemic individuals with Hb C trait should be balanced de...

background: approximately 180 mutations have been described in β-thalassemia worldwide with specific spectrum in each ethnic population. this study determines the spectrum and the frequency of β-thalassemia mutations in patients with β-thalassemia trait and sickle cell-β-thalassemia.   methods: fifteen compound heterozygous sickle cell thalassemia (sct) and 23 β-thalassemia trait patients were ...

Background: Chest X-ray is one of the examinations required for an annual health checkup. The interaction of radiation to the medium produces free radicals, which consequently causes biological changes either structural or properties of the cells. Whether the radiation from Chest X-ray upright technique affects the plasma membrane fluidity of thalassemic red blood cells (RBCs) is still unclear....

This study, based on medical anthropology and oral reports, analyzes the meanings attributed by thalassemic adults to their experiences with the treatment. Interviews were used to collect data, which were analyzed through inductive thematic analysis. Eleven young adults, six of whom were men, at different ages, with different educational levels and occupations participated in the study. The mea...

Several human genetic disorders of hemoglobin have risen in frequency because of the protection they offer against death from malaria, sickle-cell anemia being a canonical example. Here we address the issue of why this highly protective mutant, present at high frequencies in subSaharan Africa, is uncommon in Mediterranean populations that instead harbor a diverse range of thalassemic hemoglobin...

Background: Approximately 180 mutations have been described in β-thalassemia worldwide with specific spectrum in each ethnic population. This study determines the spectrum and the frequency of β-thalassemia mutations in patients with β-thalassemia trait and sickle cell-β-thalassemia. Methods: Fifteen compound heterozygous sickle cell thalassemia (SCT) and 23 β-thalassemia trait patients were st...

background: the reproductive and sexual health issues concerning persons affected by thalassemia major are complex. the study was planned to investigate the psychological attitudes and expectations in a group of thalassemic pregnant women attending hospital for regular blood transfusion. methods : this is a preliminary cross-sectional study involving 20 consecutive thalassemic patients and a co...