BACKGROUND Gastro-entero-pancreatic/neuroendocrine (NET) tumors are highly vascularized neoplasms. However, our knowledge concerning circulating levels of the angiogenic factors in NET patients still remains insufficient. METHODS The aim of this study was to measure plasma concentrations of VEGF, angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2), soluble Tie-2, endostatin, osteopontin (OPN) and ...

Performance appraisal is a process which help shareholders make informed and optimal investment decisions. In recent decades, a long stream of research has devoted particular attention to the importance and impact of financial decisions on firm performance and firm value. The present study thus is primarily concerned with investigating the association between free cash flow and institutional ow...

corporate entrepreneurship is one the key factors for long term success of family firms. therefore, continuing the entrepreneurial behaviors in the following generations of the family firm, which is called transgenerational entrepreneurship, is of paramount importance. among different factors, the successor has a key role in the development of entrepreneurship in the firm. so, the family firm m...

the purpose of this reaserch is to measure the phase equilibrium data of the ternary system (water + phosphoric acid + 1-nonanol) at different temperatures. experimental solubility curves and tie-line points for the system were obtained at t = 298.2, 308.2 and 318.2 k and ambient pressure. the binodal curve data were detected by the cloud point method. the mass fractions of each layer were achi...

This paper presents the performance-based optimization of strut-and-tie models in reinforced concrete beam-column connections. The performance-based optimization (PBO) technique is employed to investigate optimal strut-and-tie models in reinforced concrete beam-column connections. Developing strut-and-tie models in reinforced concrete beam-column connections is treated as a topology optimizatio...

Why some dyadic interactions are more likely than others to trigger hinder the generation of novel and useful ideas? To investigate this question, we examine the attributes of dyadic ties that influence the generation of creative ideas, and how the strength of influence changes contingently on the mix use of communication media. Our study extends previous research by examining the impacts of Si...

Angiopoietin-1 (Ang-1) belongs to a novel family of endothelial growth factors that function as ligands for an endothelialspecific receptor tyrosine kinase (Tie-2). The Ang-/Tie-2 system may contribute to angiogenesis and vascular remodeling by mediating interactions of endothelial cells with smooth muscle cells and pericytes. The spatial distribution and temporal expression of Ang-1 and Tie-2 ...

The expression of angiopoietin1 and 2 (ang1 and 2) and their receptor tie-2 was studied in avian embryos using in situ hybridization. Ang1 was transcribed in the mesenchymal cells surrounding venous endothelium expressing tie-2. By contrast, ang2 was transcribed around arteries in which the endothelium down-regulated tie-2 mRNA. The aorta and large arteries of the heart outflow tract were never...