Glaucoma is one of the most common causes of blindness and it is becoming even more important considering the ageing society. Because healing of died retinal nerve fibers is not possible early detection and prevention is essential. Robust, automated mass-screening will help to extend the symptom-free life of affected patients. We devised a novel, automated, appearance based glaucoma classificat...

The formation of segmental grooves during mid embryogenesis in the Drosophila epidermis depends on the specification of a single row of groove cells posteriorly adjacent to cells that express the Hedgehog signal. However, the mechanism of groove formation and the role of the parasegmental organizer, which consists of adjacent rows of hedgehog- and wingless-expressing cells, are not well underst...

ow everybody loves Puerto Rican culture,” observed a Puerto Rican schoolteacher and festival organizer, “but that’s exactly the problem. Now you have people that don’t know culture but are putting together events because it’s fashionable. That’s why we need the Institute of Puerto Rican Culture, so people don’t devalue our culture.” Culture is certainly fashionable in Puerto Rico. In addition t...

Root formation in plants involves the continuous interpretation of positional cues. Physiological studies have linked root formation to auxins. An auxin response element displays a maximum in the Arabidopsis root and we investigate its developmental significance. Auxin response mutants reduce the maximum or its perception, and interfere with distal root patterning. Polar auxin transport mutants...

This paper discusses revenue inequalities, utility equivalence, and a model of competition in auction design in symmetric equilibrium of k-price auctions, k ≥ 1, all in the setup of symmetric independent-private-value auctions. Our recommendation to organizers of auctions is to conduct k-price auctions, k ≥ 3 in environments in which buyers are risk-seeking. The recommendation is given both for...

An organizer population has been identified in the anterior end of the primitive streak of the mid-streak stage embryo, by the expression of Hnf3beta, Gsc(lacZ) and Chrd, and the ability of these cells to induce a second neural axis in the host embryo. This cell population can therefore be regarded as the mid-gastrula organizer and, together with the early-gastrula organizer and the node, const...

Expression of the LIM homeobox gene lhx1 (lim1) is specific to the vertebrate gastrula organizer. Lhx1 functions as a transcriptional regulatory core protein to exert ;organizer' activity in Xenopus embryos. Its ancient paralog, lhx3 (lim3), is expressed around the blastopore in amphioxus and ascidian, but not vertebrate, gastrulae. These two genes are thus implicated in organizer evolution, an...