The drug approval process must determine efficacy validly, detect risks prudently, and do both in a timely and efficient way. Several high-profile medication withdrawals in recent years have refocused attention on the difficulty of the US healthcare system in meeting these goals. Rofecoxib (Vioxx, Merck) was taken off the market in September 2004 after 5 years of use by 20 million people, when ...

BACKGROUND AND OBJECTIVES Cognitive models of anxiety disorders view safety-seeking behaviors (i.e., avoidance, washing, etc.) as playing a crucial role in the maintenance of irrational fear. An explanation of how these behaviors may contribute to the maintenance of unrealistic beliefs is that patients use their safety behaviors as a source of information about the situation (behavior as inform...

Preparing the books to read every day is enjoyable for many people. However, there are still many people who also don't like reading. This is a problem. But, when you can support others to start reading, it will be better. One of the books that can be recommended for new readers is there must be a pony in here somewhere. This book is not kind of difficult book to read. It can be read and unders...

The Colombian Association of Psychiatry continues to work in different areas (professional and scientific issues) with the aim of improving the profession for its members. As you will have noted, from the scientific standpoint, the journal, as a means of communicating the knowledge base generated by mental health professionals, both national and international, strives for continued improvement ...