BACKGROUND Several factors are believed to influence the development and experience of pain. Human clinical pain models are central tools, in the investigation of basic physiologic pain responses, and can be applied in patients as well as in healthy volunteers. Each clinical pain model investigates different aspects of the human pain response. Brief thermal sensitization induces a mild burn inj...

Foster, K. G., Hey, E. N., and O'Connell, B. (1971). Archives of Disease in Childhood, 46, 444. Sweat function in babies with defects ofthe central nervous system. Sweat function has been studied as part of the full neurological examination of 50 full-term infants with malformation of the central nervous system. 26 of the children were less than 1 month old at the time of examination, and a fur...

Functional magnetic resonance imaging of the human spinal cord is carried out with a graded thermal stimulus in order to establish the relationship between signal changes and neural activity. Studies of the lumbar spinal cord in 15 healthy subjects with 10 degrees C stimulation of the skin overlying the calf demonstrate a pattern of activity that matches the neuronal anatomy of the spinal cord....

The present study investigated the effect of acute thermal stimulation in conscious rats on the production of Fos, a marker of increased neuronal activity, in spinally projecting and nitrergic neurons in the hypothalamic paraventricular nucleus (PVN). The PVN contains a high concentration of nitrergic neurons, as well as neurons that project to the intermediolateral cell column (IML) of the spi...

UNLABELLED The goal in the current study was to examine the analgesic effects of a pinch grip-force production task and a working memory task when pain-eliciting thermal stimulation was delivered simultaneously to the left or right hand during task performance. Control conditions for visual distraction and thermal stimulation were included, and force performance measures and working memory perf...

background: one of the first‑line assessment tools for fetal surveillance is nonstress test (nst), although it is limited by a high rate of false‑nonreactive results. this study was performed to investigate if external stimulation from vibroacoustic and halogen light could help in provoking fetal responsiveness and altering nst results. materials and methods: this is a clinical trial. sampling ...

The influence of a chronically implanted spinal cannula on the nociceptive response induced by mechanical, chemical or thermal stimuli was evaluated. The hyperalgesia in response to mechanical stimulation induced by carrageenin or prostaglandin E2 (PGE2) was significantly increased in cannulated (Cn) rats, compared with naive (Nv) or sham-operated (Sh) rats. Only Cn animals presented an enhance...

OBJECTIVES Electroconvulsive shock therapy (ECT) has been widely used as an effective and established treatment for refractory depression and schizophrenia. Some reports have shown that ECT is also effective for treating refractory neuropathic pain. DESIGN In a rat model of neuropathic pain produced by chronic constrictive injury (CCI) of the sciatic nerve, thermal hyperalgesia, and mechanica...

BOULANT, J. A., AND K. E. BIGNALL. Hypothalamic neuronal responses to peripheral and deep-body temperatures. Am. J. Physiol. 225(6) : 1371-1374. 1973.-Single-unit activity was recorded in the anterior hypothalamic-preoptic area of anesthetized rats and ground squirrels. The local thermosensitivity (i.e., impulses/set . “C) of 28 units was determined by their change in firing rate to changes in ...

Intracellular stimulation of each of the nine identified neurons released a specific withdrawal reactions. These cells fire in response to strong tactile, light and thermal stimuli releasing escape behavior, and are assumed to be command neurons.