نتایج جستجو برای: thymidine uptake
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of blood was determined in 33 cases of chronic lymphocytic leukemia, in widely varying disease and treatment status. Eight patients (three in complete peripheral remission and five with lymphocytosis) had uptake values within the nor mal range. These patients appeared to have unusually be nign disease, requiring little or no therapy, and all were in good functional status at last follow-up. Six...
eluent. Uptake patterns were highly individual, and large differences were noted both in the baseline uptakes and in the effect of 5-fluorouracil on precursor incorporation. Neither tissue of origin nor control uptake influenced the in vitro response to the drug. A decrease in formate incorporation was usually associated with a reciprocal increase in thymidine incorporation. Clinical data conce...
1. The role of enhanced aerobic glycolysis in the transformation of rat thymocytes by concanavalin A has been investigated. Concanavalin A addition doubled [U-(14)C]glucose uptake by rat thymocytes over 3h and caused an equivalent increased incorporation into protein, lipids and RNA. A disproportionately large percentage of the extra glucose taken up was converted into lactate, but concanavalin...
Targeted therapies have yet to have significant impact on the survival of patients with bladder cancer. In this study, we focused on the urea cycle enzyme argininosuccinate synthetase 1 (ASS1) as a therapeutic target in bladder cancer, based on our discovery of the prognostic and functional import of ASS1 in this setting. ASS1 expression status in bladder tumors from 183 Caucasian and 295 Asian...
the effect of dietary sucrose on dna formation in rat liver and kidney compared with that of starch was studied. male, weanling rats were fed for 6 and 14 days on diets containing 68% 'sucrose or 68% starch, and liver and kidneys were examined for 1ilie amount and rate of formation of dna; and also for content of fat, protein, and moisture. food intake and weight gain were estimated. sucrose fe...
Labeled spermatocytes from locusts killed 0, 1, 2, 3, 4, and 6 days after exposure to tritiated thymidine were examined with the electron microscope to determine their meiotic stage. It was found that tritiated thymidine uptake in young spermatocyte nuclei is completed some 24 hours before synaptinemal complexes are formed. It is concluded that in the locust, premeiotic DNA synthesis is complet...
A simple physical chemical method of transferring genes into eucaryotic cells is described. Electric impulses in the intensity range of 5-10 kV/cm with a duration of 5-10 bs were found to appreciably increase the uptake of DNA into cells. After electric field treatment, stable transformants were obtained in a system containing mouse cells deficient in thymidine kinase and a plasmid DNA harbouri...
Aqueous extracts of murine embryonic or uterine tissue, or [(6)N]O(2)'-dibutyryl 3',5'-adenosine monophosphate (dbc-AMP) which were cytostatic for the murine mastocytoma P815Y in vitro also induced rapid changes in the incorporation of exogenous nucleosides into acid-insoluble material. However, these alterations were not a consequence of growth arrest. Different dose-response curves were obtai...
Lipopolysaccharide induces a synergistic uptake of tritiated thymidine in peripheral blood lymphocytes (PBL) when cultured with phytohemagglutinin or concanavalin A as compared to PBL incubated only with phytohemagglutinin or concanavalin A. In this study we investigated which subpopulations(s) of PBL is involved in this synergistic increase in deoxyribonucleic acid synthesis. Separation of PBL...
CAMA-1 cells, isolated from malignant pleural effusion, are grown in long-term cultures as monolayers. The rate of growth is dependent upon fetal bovine serum and estradiol. These cells also exhibit a dose response to added 17 beta-estradiol with respect to the incorporation of radiolabeled thymidine into cells. The uptake is increased at low levels of estradiol and decreased at pharmacological...
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