The development of tumorous growths in the pituitary glands of mice following the injection of radioiodine and subsequent radiothyroidectomy was first reported by Gorbman (8), who reasoned that thyroid destruction was not the principal fac tor in the production of these growths, since pitui tary tumors had not been induced when the thy roid gland was chronically depressed by goitrogens. Later, ...

Introduction: Thyroid gland fibrosarcomas are extremely rare tumors, and only very few cases have been described in the literature. There are no set recommendations along with follow-ups regarding the treatment of these tumors. Moreover, the prognosis is poor with a very short life expectancy.   Case Report: We present an 81-year-old patient who was suffering from increa...

background: radiotherapy plays an important role in the management of most malignant and many benign primary central nervous system (cns) tumors. radiotherapy affects both tumor cells and uninvolved normal cells; so, it is important to estimate absorbed dose to organs at risk in this kind of treatment. the aim of this study was to determine the absorbed dose to chiasma, lens, optic nerve, retin...

The majority of familial medullary thyroid neoplasms are associated with germ-line mutations of the RET proto-oncogene, yet very little is known about the mechanisms involved in the pathogenesis of familial and sporadic nonmedullary thyroid tumors. A subset of thyroid tumors have loss of heterozygosity of chromosome 10q22-23, a region harboring the gene responsible for Cowden disease, an autoso...

Ovarian tumors can be classified by their origin - epithelial tumors, germ cell and stromal tumors. Malignant struma ovarii (MSO) are 0.01% of all ovarian In order to as a ovarii, more than 50% the teratoma consists thyroid tissue. The tissue in exhibits same histological physiological properties that cervical Poorly differentiated carcinoma (PDTC) is an extremely rare occurrence when arising f...

Objective(s): As the most prevalent endocrine system malignancy, papillary thyroid carcinoma had a very fast rising incidence in recent years for unknown reasons besides the fact that the current methods in thyroid cancer diagnosis still hold some limitations. Therefore, the aim of this study was to improve the potential molecular markers for diagnosis of benign and malignant thyroid nodules to...

The four regulatory subunits (R1A, R1B, R2A, R2B) of protein kinase A (PKA) are differentially expressed in several cancer cell lines and exert distinct roles in both cell growth and cell differentiation control. Mutations of the PRKAR1A gene have been found in patients with Carney complex and in a minority of sporadic anaplastic thyroid carcinomas. The aim of the study was to retrospectively e...

nloaded plastic thyroid carcinomas are deadly tumors that are highly invasive, particularly into the bones. gh oncogenic Ras can transform thyroid cells into a severely malignant phenotype, thyroid carcinoo not usually harbor ras gene mutations. Therefore, it is not known whether chronically active Ras butes to thyroid carcinoma cell proliferation, although galectin-3 (Gal-3), which is strongly...

Granular cell tumor presenting as a thyroid mass is very rare. It may arise from the thyroid gland or from the tissues/organs adjacent to the thyroid gland. It may cytologically mimick other common thyroid tumors. The accurate evaluation of these tumors may be important for management. We describe a granular cell tumor arising from the tissue adjacent to the thyroid gland and with multiple orga...