BACKGROUND ROC curve analysis is used to compare the overall diagnostic accuracy of tests, but its application to subgroups selected by a concentration range of only one marker may show severe biases. We developed a new approach, which we have named discordance analysis characteristics (DAC). METHODS The DAC method is based on a generalization of the McNemar test so that for a given pair of c...

The purpose of this paper is to discuss and assess the tariff policy that TPSA has been pursuing while the regulatory agencies have been remaining entirely indifferent. The most important provisions of the imperfect regulatory framework and market structure are described. The evolution of tariffs, which has not contributed towards the rebalancing during last several years, and their internation...

Актуальність. Глутаматна ексайтотоксичність та внутрішньочерепна гіпертензія являють собою потенційні мішені щодо можливих розробок патогенетичної терапії уражень мозку, зокрема тих, що асоційовані з високими значеннями внутрішньочерепного тиску. Мета. Методами хемоінформатики обґрунтувати внутрішньовенне застосування адемолу, виявити здатність адемолу блокувати β-адренорецептори, а також за кр...

INTRODUCTION We aimed to assess the relationship between prostate volume (PV) and high grade prostate carcinoma (HGPCa) in patients with benign and suspicious digital rectal examination (DRE) in our prostate biopsy cohort. MATERIALS AND METHODS Between 2009-2012, 759 consecutive initial transrectal systematic 12 cores prostate biopsies were included. PVs were calculated with transrectal ultra...

The Lie Algebra package LieMath written in the Mathematica language constructs the beamline map in a singleexponent Lie generator form. The algorithm (a BCH-based map concatenation) has been recently enhanced with Truncated Power Series Algebra (TPSA) techniques. The polynomials produced by the series expansion of the Hamiltonian are replaced with arrays of coefficients (derivative structures) ...

On the basis of the results of magneto-optical studies and their comparison with the outcome of medical tests magneto-optical MOCB and tPSA serum markers of cancer/recovered patient are presented. Status of the cancer serum donor is recognized as presence of the laevorotatory optical active molecules of ρ density in serum while status of the recovered donor is recognized as quantitative dominat...

A cross sectional pilot study was carried out to look into the usefulness of percent free prostate specific antigen (fPSA) in the diagnosis of prostatic cancer in HUSM patients. All patients who attended surgical clinic and admitted to surgical wards with signs and symptoms of prostate problems during the study period were taken as the study subjects. Total prostate specific antigen (tPSA) was ...

Introduction: The clinical value of PSA for prostate cancer early detection has been questioned primarily due to its poor specificity for clinically relevant disease, namely high grade prostate cancer. This is especially true at PSA levels lower than 4 ng/mL, generally considered to be within the normal range. However, PSA values between 1.54 ng/mL have been referred to as the PSA Danger Zone b...

Abstract Background Androgen deprivation therapy (ADT) for advanced prostate cancer (aPCa) causes changes in body mass index (BMI) and the performance status depending on extent of remission. The aim this study is to quantify these changes. Methods A prospective cohort a public tertiary urology centre Enugu, southeast Nigeria. With appropriate sample size determined, men with aPCa ADT, by surgi...

The two-partner secretion (TPS) systems of Gram-negative bacteria consist of a large secreted exoprotein (TpsA) and a transporter protein (TpsB) located in the outer membrane. TpsA targets TpsB for transport across the membrane via its ∼30-kDa TPS domain located at its N terminus, and this domain is also the minimal secretory unit. Neisseria meningitidis genomes encode up to five TpsAs and two ...