OBJECTIVE To evaluate the performance of total PSA (tPSA), the free/total PSA ratio (f/tPSA), complexed PSA (cPSA) and the complexed/total PSA ratio (c/tPSA) in prostate cancer detection. METHODS Frozen sera of 442 patients have been analysed for tPSA, free PSA (fPSA) and cPSA. 131 patients had prostate cancer and 311 patients benign prostatic hyperplasia. RESULTS Differences in the distrib...

OBJECTIVE To assess, using artificial neural networks (ANNs), human glandular kallikrein 2 (hK2), prostate-specific antigen (PSA), and percentage free/total PSA (f/tPSA), for discriminating between prostate cancer and benign prostatic hyperplasia (BPH). MATERIAL AND METHODS Serum samples from 475 patients with prostate cancer (n = 347) or BPH (n = 128) within the PSA range of 1-20 ng/mL were ...

AIM To assess the efficacy and limitation of free/total prostate-specific antigen ratio (f/tPSA) at a single institution in Japan, focusing on the avoidance of pointless prostate biopsies. METHODS In total, 631 men between 44 and 93 years old (mean 69.8 years) with elevated PSA underwent power-Doppler ultrasoundgraphy-guided transrectal 10-core prostate biopsies at Niigata Cancer Center Hospi...

OBJECTIVES To examine the distribution of total prostate-specific antigen (tPSA) and percentage of free/total PSA (%f/tPSA) values in patients undergoing prostate cancer screening in Canada. METHODS The data from 4 consecutive annual prostate cancer screening events held in Montreal, Canada were examined with respect to age, tPSA, and %f/tPSA in 3222 men. RESULTS Within the entire cohort, t...

Background: To investigate the differential value of the percentage of free to total prostate specific antigen (f/tPSA) in the diagnosis of prostate cancer (PCa) and benign prostatic hyperplasia (BPH) when the tPSA greater than or equal to 10 ng/mL. Methods: A retrospective study was performed among 361 cases of PCa or BPH whose tPSA greater than or equal to 10 ng/mL and whose diagnosis were co...

BACKGROUND The comparability of total and free prostate-specific antigen (tPSA and fPSA) results among commercial PSA assays has been suggested to be improved by calibration to WHO PSA reference materials and the development of equimolar-response assays. To characterize the current situation, we assessed 5 frequently used commercial assay combinations for tPSA and fPSA regarding the interchange...

BACKGROUND The aim of this study was to compare the diagnostic utility of a new assay that measures all forms of prostate-specific antigen complexed (cPSA) to serum proteins except alpha(2)-macroglobulin with the assay of free PSA (fPSA) and the corresponding ratios to total PSA (tPSA) to improve the differentiation between benign prostatic hyperplasia (BPH) and prostate cancer (PCa). METHODS...

BACKGROUND To determine a cut-off point of tPSA and PSAD to prevent unnecessary invasive cancer-diagnosing tests in the community. METHODS This study was performed on 688 consecutive patients referred to our center due to prostatism, suspicious lesions on digital rectal examination and/or elevated serum PSA levels. All patients underwent transrectal ultrasound guided biopsies and obtained PSA...

Objective: The aim of this study is to evaluate the diagnostic performance of PSAbased parameters in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and to determine the relation between serum PSA and histopathological grade in PCa. Methods: This retrospective study includes data of 320 patients with PCa (n: 155) and BPH patients (n: 165). Serum PSA levels and Gleason scores of pa...

In this study, a temperature parallel simulated annealing with adaptive neighborhood (TPSA/AN) for continuous optimization problems is introduced. TPSA/AN is based on the temperature parallel simulated annealing (TPSA), which is suitable for parallel processing, and the SA that Corana developed for continuous optimization problems. The moves in TPSA/AN are adjusted to have equal acceptance rate...