background: increased levels of total and lipid-associated sialic acid (tsa and lasa) have been reported in the sera of patients with benign or malignant tumors and also could be regarded as newly important clinical criteria for the diagnosis of cancer. this study has investigated the differences of tsa and lasa contents between cancer patients and healthy individuals and evaluated their correl...

Sepsis, a serious clinical problem, is characterized by a systemic inflammatory response to infection and leads to organ failure. Toll-like receptor (TLR) signaling is intimately implicated in hyper-inflammatory responses and tissue injury during sepsis. Histone deacetylase (HDAC) inhibitors have been reported to exhibit anti-inflammatory properties. The aim of this study was to investigate the...

PURPOSE To examine the effects of a histone deacetylase inhibitor, Trichostatin A (TSA), on the behavior of macrophages and subconjunctival fibroblasts in vitro and on ocular surface inflammation and scarring in vivo using an alkali burn wound healing model. METHODS Effects of TSA on expression of inflammation-related growth factors or collagen I were examined by real-time RT-PCR or immunoass...

PURPOSE Therapy for advanced renal cell carcinoma (RCC) is ineffective in the majority of patients. We have previously reported that retinoid-induced up-regulation of retinoic acid receptor beta (RARbeta) correlated with antitumor effects in RCCs. Recent studies show that there is a reduction in the level of RARbeta2 expression in cancer cells due in part to histone hypoacetylation. Therefore, ...

Abstract This study aims to investigate the underlying mechanisms driving changes in contemporaneous relationship between El Niño–Southern Oscillation (ENSO) and tropical South Atlantic (TSA) sea surface temperatures (SST) during boreal summer over past century. Our findings indicate that negative TSA–ENSO is primarily attributed persistent ENSO years rather than transition or development years...

This work aimed to study the structural features and mechanisms of thermoinactivation hyperthermophilic L-asparaginase (L-ASNase) from archaea Thermococcus sibiricus (TsA) in comparison with bacterial L-ASNases Melioribacter roseus (MrA) Rhodospirillum rubrum (RrA). The catalytic parameters L-asparagine hydrolysis under optimal conditions (pH 9) were determined for these enzymes by circular dic...

This paper presents a Tabu Search Algorithm (TSA) for container loading problems with a container to be loaded. The TSA is based on a two-stage procedural approach. While alternative stowing plans are generated directly using an integrated greedy heuristic, the execution of the heuristic is controlled by means of a superior Tabu Search. The TSA considers several restrictions of practical releva...

Davis, Francesca J., Jyothish B Pillai, Madhu Gupta, and Mahesh P. Gupta. Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of -MHC and cardiac tubulins: implication for gain in cardiac muscle contractility. Am J Physiol Heart Circ Physiol 288: H1477–H1490, 2005. First published September 23, 2004; doi:10.1152/ajpheart.00789.2004.— Histone deacet...

Tanshinone IIA (TSA) is one of the major lipophilic components of Salvia miltiorrhiza Bunge reported to exhibit an antitumor effect. The exact intracellular signaling mechanisms involved remain elusive and were therefore the subject of this study. The process of angiogenesis is related to tumor progression, invasion and metastasis and is generally perceived as an indicator of tumor prognosis. A...