In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Chroscinski et al., 2015) that described how we intended to replicate selected experiments from the paper "The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors "(Willingham et al., 2012). Here we report the results of those experiments. We fou...

background: monoclonal antibodies have been employed extensively for the identification of leishmania species, development of diagnostic tests and in the characterization of defined leishmanial antigens. objectives: identification and characterization of  leishmania spp. directly from cutaneous lesions of infected individuals. methods: an immunoperoxidase test (avidin-biotin technique) using mo...

this study was undertaken to examine the ability of spect in differentiation of a pulmonary lesion suspecions of lung cancr. a total of 170 patients with suspected lung cancer were studied. a dose of tl-201 chloride {148-296 mbq) was injected intravenously and tomographic early and delayed scans were obtained at 15 miniutes and 3 hours post injection, respectively. delayed tl-201 spect visulize...

In addition to the well-established effector functions of IgGs, including direct cytotoxicity and antibody-dependent cellular cytotoxicity, some populations of IgGs may exert anti-inflammatory effects. Here, we describe a population of antibodies that form in the natural course of metastatic cancer and contain glycans that terminate with sialic acid. We demonstrate that both the titer of these ...

how to cite this article: aghayan golkashani h, hatami h, farzan a, mohammadi hr, nilipour y, khoddami m, jadali f. tumors of the central nervous system: an 18-year retrospective review in a tertiary pediatric referral center. iran j child neurol. summer 2015;9(3):24-33.   abstract objective few studies exist on the demographics and trends of pediatric central nervous system (cns) tumors in ira...

As a part of a program directed toward the elucidation of the role of viruses in mouse and human breast cancer, a variety of immunological techniques were applied to a study of the humoral immune response of mice and of humans to their breast tumors. Tumor-bearing mice were found to produce antibodies against a complex array of tumor cell-associated antigens, including mouse mammary tumor virus...

The coupling of specific antibodies to imaging agents often improves imaging specificity. However, free amine groups designed for the coupling can cause nonspecific binding of the imaging agents. We report here development of a nanocarrier, MnMEIO-silane-NH2-mPEG nanoparticles (NPs), consisting of a manganese-doped iron oxide nanoparticle core (MnMEIO), a copolymer shell of silane and amine-fun...

cutaneous round cell tumors have been classified as mast cell tumor (mct), histiocytoma (hct), lymphosarcoma, undif-ferentiated round cell tumors and occasionally rhabdomyosarcoma in veterinary medicine. an adult cock (gallus domesticus) showing a large solitary integument mass raised on dorso bilateral of cervical part, extending to intercapsular and cranial mid part of the back was referred t...

background: the study was targeted to report the appearance of coproantigens in feces and circulating antibodies in the serum of fasciola gigantica  experimentally infected rabbits. methods: copro hyper immune serum (his) and excretory-secretory hyper immune serum (es his) antigens were used in a sandwich elisa for the detection of f. gigantica antigens in feces of 12 rabbits experimentally inf...

mycoplasma genitalium (m.genitalium) is a sexually transmitted pathogen. detection of this microorganism in clinical specimens by culture is rather difficult and time consuming. the aim of this study was to produce polyclonal antibody against a synthetic peptide from p110 protein of m.genitalium in order to develop a diagnostic tool for detection of this microorganism in clinical specimens. a s...