This article discusses type 1 diabetes mellitus, which results from insulin deficiency caused by autoimmune destruction of the insulin-producing beta-cells in the pancreatic islets of Langerhans. The autoimmune response against islet beta-cells is believed to result from a disorder of immunoregulation. According to this concept, T lymphocytes (T cells) autoreactive to certain beta-cell constitu...

Prevention of loss of b cells in type 1 diabetes is a major goal of current research. Knowledge of the genetic susceptibility, increasing ability to predict who may be at risk, recognition of the potential clinical impact of residual insulin secretion after diagnosis, and development of new immunomodulatory agents have supported an increasing number of clinical trials to prevent b-cell loss. In...

INTRODUCTION/BACKGROUND Type 1 diabetes is a chronic autoimmune condition characterized by destruction of insulin-producing β cells within the pancreatic islets. It is associated with considerable morbidity and mortality. Incidence levels are rising worldwide. SOURCES OF DATA Pubmed search (Nov 2010) using keywords: Type 1 diabetes, prevention, trials, immunotherapy. AREAS OF AGREEMENT The ...

The numbers of people with type 2 diabetes are rising rapidly around the world, making it imperative to develop and introduce methods of preventing the condition. A series of clinical trials over the last decade has shown conclusively that lifestyle interventions focusing on physical activity, diet, and weight loss can reduce the risk of developing type 2 diabetes by approximately 60%. Trials e...

Aggressive treatment of hypertension is effective in reducing both microvascular and macrovascular complications in type 2 diabetes, and target BP less than 130/85 or 130/80 mmHg are now recommended. Inhibition of renin angiotensin aldosterone system (RAAS) plays an essential role in the treatment of hypertension and diabetes-related complications. Studies focusing on renal end-points suggest t...

As the human and economic cost of type 2 diabetes has surged, focus on its prevention has intensified. Clinical trials across the globe have demonstrated that diabetes can be prevented in high-risk populations over a wide range of cultures and ethnicities [1–12]. Further, reduction in diabetes onset is observed beyond the time of the interventions, albeit attenuated [13, 14]. Waning benefit pos...

a:4:{s:10:"Background";s:563:"Type II diabetes is a metabolic disorder that can gradually cause damage to the function of many organs such as the gonads. It is believed that poor blood glucose control is the main cause of diabetic side effects. Avocado (Persea americana) is a native tree of Central and South America that has traditionally been used due to its antioxidant, antiinflammatory, anti...

conclusions the results of the present study give some evidence that allows us to conclude that hardiness and coping strategies affect occupational life quality for both people suffering from type ii diabetes and healthy people. therefore, it is proposed that people strengthen their hardiness and coping strategies, in order to improve their occupational life quality. background due to the epide...

Our objective was to review modelling methods for type 2 diabetes mellitus prevention cost-effectiveness studies. The review was conducted to inform the design of a policy analysis model capable of assisting resource allocation decisions across a spectrum of prevention strategies. We identified recent systematic reviews of economic evaluations in diabetes prevention and management of obesity. W...