The induction of tyrosine hydroxylase in the nerve terminals of the rat heart by reserpine lags behind that in the stellate ganglion by two to three days. Cycloheximide given three days after reserpine blocks the further rise of the enzyme in the nerve terminals. The increase in tyrosine hydroxylase activity of the lumbar ganglion is as marked as that in the stellate ganglion. The increase of e...

Two classes of compounds have been investigated as inhibitors of purified beef adrenal tyrosine hydroxylase. Among the aromatic amino acids tyrosine analogues were found to be most potent, particularly those having an a-methyl or 3-halogen substitution. Two normal metabolites, monoand diiodo-tyrosine, were found to bevery effective inhibitors. Inhibition by the amino acid analogues was shown to...

Although it is clear that cardiac norepinephrine stores are often markedly reduced in congestive heart failure, the mechanism responsible for this depletion has not been elucidated. The objective of this study was to investigate cardiac synthesis of norepinephrine in experimental right-sided heart failure by measuring the activity of tyrosine hydroxylase, the rate-limiting enzyme in the biosynt...

Introduction: Parkinsonchr('39')s disease (PD) presentations comprise frequent movement disorders in the elderly with various symptoms consisting of motor and non-motor complications. Paeonol is a phenolic chemical agent that has shown antioxidant and anti-inflammatory effects in different disorders and promising effects on metabotropic glutamate receptors (mGluR)- and GABAA-mediated neurotrans...

BACKGROUND Sickle cell disease patients display priapism that may progress to erectile dysfunction. However, little is known about the pathophysiological alterations of corpus cavernosum in sickle cell disease. OBJECTIVE Thus, this study aimed to evaluate the functional and molecular alterations of sympathetic machinery and nitric oxide-cyclic guanosine monophosphate signaling pathway in Town...

In order to determine whether the cholinergic fibres that innervate the substantia nigra make synaptic contact with dopaminergic neurons of the substantia nigra pars compacta, a double immunocytochemical study was carried out in the rat and ferret. Sections of perfusion-fixed mesencephalon were incubated first to reveal choline acetyltransferase immunoreactivity to label the cholinergic termina...

Parkinson’s disease (PD) is a neurodegenerative characterized by the progressive degeneration of dopaminergic neurons in substantia nigra. Oxidative stress-induced neuronal death has been identified as one major causes nigrostriatal PD. The fruit Actinidia arguta (A. arguta), known sarunashi Japan, reported to show beneficial health effects such antioxidant, anti-inflammatory, anti-mutagenic, a...

Exposure to chemosensory signals from unfamiliar males can terminate pregnancy in recently mated female mice. The number of tyrosine hydroxylase-positive neurons in the main olfactory bulb has been found to increase following mating and has been implicated in preventing male-induced pregnancy block during the post-implantation period. In contrast, pre-implantation pregnancy block is mediated by...

Tyrosine hydroxylase activity was determined in eight brain regions: cerebral cortex, tuberculum olfactorium, nucleus accumbens, hypothalamus, amygdala, striatum, pons and medulla. Tyrosine hydroxylase activity was measured by the radiometric method of Hendry & Iversen (1971). After 30 days of chronic treatment, the specific activity of tyrosine hydroxylase was decreased t o a value below the s...

Acetylcholine stimulation of bovine chromaffin cells results in increased norepinephrine and epinephrine secretion accompanied by a corresponding increase in synthesis. The addition of neuropeptide Y (NPY) to the culture medium prevents the increase in catecholamine synthesis but not secretion. Treatment of chromaffin cells with nicotine produces a concentration-dependent increase in tyrosine h...