Currently there exists increasing preoccupation concerning sexual and reproductive health among teenagers; in spite of the availability of different contraceptive methods, the number of undesired pregnancies is steadily increasing. Among the products presently available for birth control, spermicides are a means that can be totally controlled by the woman and are very reliable compared to other...

After having intercourse or sex for the first time, a person may experience a range of physical or emotional reactions. Common physical reactions vary, too, and can include soreness, numbness, pleasure, orgasm, no orgasm, lubrication, no lubrication, irritation, urinary tract infection (UTI) [2], vaginal infection, or a sexually transmitted infection (STI) [3], with or without symptoms [4]. Com...

The most common cause of acute dysuria is infection, especially cystitis. Other infectious causes include urethritis, sexually transmitted infections, and vaginitis. Noninfectious inflammatory causes include a foreign body in the urinary tract and dermatologic conditions. Noninflammatory causes of dysuria include medication use, urethral anatomic abnormalities, local trauma, and interstitial cy...

We wished to obtain potential users' perspectives on vaginal microbicides from a population of women at high risk for HIV. We conducted a face-to-face survey of convenience samples (total n = 743) of drug-using women and female sexual partners of male injection drug users in Bridgeport, Connecticut, Providence, Rhode Island, and San Juan, Puerto Rico. Ninety percent of respondents said that the...

Atrophic changes of the vagina, vulva, and urinary tract have a large impact on quality of life of an elderly woman, the symptoms being progressive in nature and worsening with time. Common symptoms of urogenital atrophy include irritation, and itching; vaginal dryness, pain during sexual intercourse; and recurrent urinary tract infection (UTI). Observational studies have confirmed the high pre...

BACKGROUND/AIMS Intravaginal pentamycin is a polyene macrolide with a broad spectrum of antimicrobial activity and is effective in various forms of infectious vaginitis. We evaluated the safety, tolerability and pharmacokinetics of escalating doses of this product. METHODS Nineteen healthy volunteers were randomized to receive double blind one of five doses of intravaginal pentamycin (3, 10, ...

PURPOSE Premature ovarian insufficiency (POI) is defined as the cessation of the ovarian function before the age of 40 years. POI aetiology may be related to iatrogenic or endogenous factors and in many cases remains unclear. The aim of this review was to characterize the long-term consequences of POI. METHODS The available literature regarding the long-term consequences of POI from MEDLINE h...

OBJECTIVE To identify associations between men's self-reports of ill-fitting condoms and selected condom use problems, using an event-specific analysis. METHODS A convenience sample of men was recruited via advertisements in newspapers (two urban and one small town) and a blog on the website of a condom sales company. Men completed a questionnaire posted on the website of The Kinsey Institute...

The present study concerned with the development and characterization of metronidazole microcapsules prepared by thermal change method using different ratios (1:1, 1:2 and 1:4) of ethyl cellulose in order to select the best microcapsule formulation with a good encapsulation efficiency and drug release profile. The obtained microcapsules were discrete, spherical with free flowing properties and ...

Dehydroepiandrosterone (DHEA) is a sex steroid precursor secreted by the adrenals in humans and other primates. It converts intracellularly to bioactive androgens and estrogens [20]. DHEA and its sulfate metabolite (DHEAS) production decreases with advancing age [21]. DHEA and DHEAS play an important role in regulating body fat and the immune system. They also influence the circulation of lipop...