Potassium channels are trans-membrane proteins, which selectively transport K+ ions across cell membranes and play a key role in regulating the physiology of excitability cells and signal transduction pathways. Bothutous Schach (BS) scorpion venom consists of several polypeptides that could modulate ion channels. In this study, the effects of BS crude venom on passive and active electrophysiolo...

royan b 1 stem cell can be differentiated to specialized cell types including cardiomyocytes. this developmental change is accompanied with expression of various k + channel types. the aim of this study was to detect functional expression of k + currents from stem cell stage and one week and two weeks after differentiation into cardiomyocyte. mouse stem cell derived cardiomyocytes (es-cardiomyo...

This article describes a simple whole cell formation technique that the author invented in teaching and experiments. The implementation of the invented technique is a syringe with a hole and slot. With the newly invented technique, novices will shorten their learning curve and veterans will increase their success rate. The invented technique lightens the labor of the experimenter and improves t...

Activation of the parasympathetic nervous system has been reported to have an antiarrhythmic role during ischemia–reperfusion injury by decreasing arrhythmia triggers. Furthermore, it was that neurotransmitter acetylcholine is able modulate ATP-dependent potassium current (I K-ATP ), a crucial activated hypoxia. However, possible significance this modulation in mechanism not fully clarified. Ac...

Ion channel proteins are universal devices for fast communication across biological membranes. The temporal signature of the ionic flux they generate depends on properties intrinsic to each channel protein as well as the mechanism by which it is generated and controlled and represents an important area of current research. Information about the operational dynamics of ion channel proteins can b...