hamid gholami pour-badie

[ 1 ] - The Effects of Buthotus schach Scorpion Venom on Electrophysiological Properties of Magnocellular Neurons of Rat Supraoptic Nucleus

Potassium channels are trans-membrane proteins, which selectively transport K+ ions across cell membranes and play a key role in regulating the physiology of excitability cells and signal transduction pathways. Bothutous Schach (BS) scorpion venom consists of several polypeptides that could modulate ion channels. In this study, the effects of BS crude venom on passive and active electrophysiolo...

[ 2 ] - Anxiolytic-Like and Sedative Effects of Alcea Aucheri (Boiss.) Alef. Flower Extract in the Laboratory Rat

The present study was conducted to investigate the possible anxiolytic and sedative ofan acute administration and 4-day repeated dosing of an aqueous extract of flowers of Alceaaucheri (Boiss.) Alef. (EFA) in rats subjected to the elevated plus-maze (EPM), open-field, andhorizontal wire tests. All drugs were administered intraperitoneally. Phytochemical screeningconfirmed the presence of phenol...

[ 3 ] - The Effect of Paxilline on Early Alterations of Electrophysiological Properties of Dentate Gyrus Granule Cells in Pilocarpine-Treated Rats

The dentate gyrus of hippocampus has long been considered as a focal point for studies on mechanisms responsible for the development of temporal lobe epilepsy (TLE). Change in intrinsic properties of dentate gyrus granule cells (GCs) has been considered as an important factor responsible in temporal lobe seizures. In this study, we evaluated the intrinsic properties of GCs, during acute phase o...

[ 4 ] - The Effects of Buthotus schach Scorpion Venom on Electrophysiological Properties of Magnocellular Neurons of Rat Supraoptic Nucleus

Potassium channels are trans-membrane proteins, which selectively transport K+ ions across cell membranes and play a key role in regulating the physiology of excitability cells and signal transduction pathways. Bothutous Schach (BS) scorpion venom consists of several polypeptides that could modulate ion channels. In this study, the effects of BS crude venom on passive and active electrophysiolo...

[ 5 ] - Anxiolytic-Like and Sedative Effects of Alcea Aucheri (Boiss.) Alef. Flower Extract in the Laboratory Rat

The present study was conducted to investigate the possible anxiolytic and sedative ofan acute administration and 4-day repeated dosing of an aqueous extract of flowers of Alceaaucheri (Boiss.) Alef. (EFA) in rats subjected to the elevated plus-maze (EPM), open-field, andhorizontal wire tests. All drugs were administered intraperitoneally. Phytochemical screeningconfirmed the presence of phenol...

[ 6 ] - The Effect of Paxilline on Early Alterations of Electrophysiological Properties of Dentate Gyrus Granule Cells in Pilocarpine-Treated Rats

The dentate gyrus of hippocampus has long been considered as a focal point for studies on mechanisms responsible for the development of temporal lobe epilepsy (TLE). Change in intrinsic properties of dentate gyrus granule cells (GCs) has been considered as an important factor responsible in temporal lobe seizures. In this study, we evaluated the intrinsic properties of GCs, during acute phase o...

[ 7 ] - Assessment of the Optimal Stimulus Pattern to Achieve Rapid Dorsal Hippocampal Kindling in Rats

Introduction: Although hippocampus is the most famous brain area involved in temporal lobe epilepsy, hippocampal kindling (HK) develops very slowly. Hence, rapid kindling is usually preferred to the traditional kindling and it is widely used. In this article we aimed at finding the optimal stimulus pattern, which yields the fastest HK rate. Methods: Stimulus patterns with different duratio...

[ 8 ] - اپتوژنتیک: کنترل سلولهای زنده با استفاده از نور

یکی از چالشهای بزرگ در علوم اعصاب دانستن این است که چطور رفتارهای خاص مانند غذا خوردن، خشم، شناخت و حرکت از فعالیت و برهمکنش سلولهای منفرد در شبکه های عصبی ناشی می‌شوند. دستکاریهای ژنتیکی، فارماکولوژیکی و یا تخریب و آسیب به یک ناحیه مغزی برای بررسی پاسخ شبکه عصبی در زمان انجام یک رفتار بکار گرفته می‌شوند. این روشها فاقد دقت زمانی در سیگنالینک و کدگذاری عصبی هستند. با استفاده از اپتوژنتیک محققین...

[ 9 ] - Voltage-Gated Sodium Channels Modulation by Bothutous Schach Scorpion Venom

Buthotus schach is one of the dangers scorpion in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. In the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...

[ 10 ] - بررسی تغییرات پارامترهای کیندلینگ در مدل آزمایشگاهی صرع الکتریکی کلاسیک پس از ضربه مغزی

زمینه مطالعه: آسیب‌های ناشی از ضربه‌های مغزی (Traumatic brain injury) یکی از مشکلات پزشکی است. یکی از پیامدهای آسیب مغزی، دچار شدن به بیماری صرع (Post Traumatic Epilepsy; PTE) می باشد. هدف: هدف از این مطالعه بررسی تغییرات پارامترهای کیندلینگ در مدل آزمایشگاهی صرع الکتریکی کلاسیک پس از ضربه مغزی می‌باشد. روش کار: 24 سر موش صحرایی نر نژاد ویستار با استفاده از مدل صرعی کیدلینگ الکتریکی کلاسیک ...

[ 11 ] - بررسی خواص مکانیکی و ریزساختار قطعات کاربید تنگستن-10درصد وزنی کبالت حاوی ممانعت کننده رشد دانه کاربید تانتالیم

پودر کاربید تنگستن-10 درصد وزنی کبالت بااستفاده از آسیاب سیاره ای با متوسط اندازة ذرات اولیه حدود 5/0 میکرون آسیاب شد. نسبت وزنی گلوله به پودر به منزلة متغیر آسیاب درنظرگرفته شد. سپس پودر با میکروسکوپ?های الکترونی روبشی و عبوری و پراش پرتو ایکس بررسی شد. پس از تحلیل نتایج، نسبت وزنی 15 مناسب?ترین نسبت وزنی به شمار آمد. در این نسبت، اندازة دانه و ذرات کاربید تنگستن به یک میزان تا 39 نانومتر کاهش...