نتایج جستجو برای: β interferon β
تعداد نتایج: 243008 فیلتر نتایج به سال:
رساله حاضر با هدف بررسی عوامل موثر بر هویت اجتماعی دانشجویان انجام گرفته است. چارچوب نظری تحقیق، برگرفته از نظریات «جورج هربرت مید»، «آنتونی گیدنز»، «پیتر بورک» و «هنری تاجفل»، می باشد. که طبق این چارچوب نظری، متغیرهایی نظیر پایگاه اجتماعی- اقتصادی، احساس تعلق به خانواده، احساس تعلق به گروه همسالان، احساس تعلق به دانشگاه، گستره شبکه ارتباطی، جنسیت، میزان اعتماد به نفس و میزان استفاده از رسانه ه...
Gene associated with retinoid-interferon-β-induced mortality (GRIM)-19, was originally identified as a critical regulatory protein necessary for Interferon-β-Retinoic acid-induced cell death. Overexpression of GRIM-19 activates cell death and its suppression or inactivation promotes cell growth. GRIM-19 targets multiple proteins/pathways for exerting growth control and cell death. However, GRIM...
Malignant ascites manifests as an end-stage event during the progression of a number of cancers and lacks a generally accepted standard therapy. Interferon-β (IFN-β) has been used to treat several cancer indications; however, little is known about the efficacy of IFN-β on malignant ascites. In the present study, we report on the development of a novel, engineered form of human and murine IFN-β,...
amyloid-β (aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in alzheimer’s disease pathology.uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...
Lung disease in cystic fibrosis (CF) is often exacerbated following acute upper respiratory tract infections caused by the human rhinovirus (HRV). Pathophysiology of these exacerbations is presently unclear and may involve deficient innate antiviral or exaggerated inflammatory responses in CF airway epithelial cells. Furthermore, responses of CF cells to HRV may be adversely affected by pre-exp...
UNLABELLED The course of hepatitis C virus (HCV) infection and disease progression involves alterations in lipid metabolism, leading to symptoms such as hypocholesterolemia and steatosis. Steatosis can be induced by multiple mechanisms, including increases in lipid biosynthesis and uptake, impaired lipoprotein secretion, and/or attenuation of lipid β-oxidation. However, little is known about th...
BACKGROUND Interferon-β (IFN-β) is an effective drug in multiple sclerosis (MS) but it may cause acute exacerbation of MS following the initiation of treatment. This study evaluated patients with rapid exacerbation of multiple sclerosis (REMS) following the initiation of IFN-β. METHODS We retrospectively reviewed the clinical records of 2350 patients with multiple sclerosis who started treatm...
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