The inhibition effect of several beta-lactam antibiotics on the uptake of [14C]benzylpenicillin (PCG) into isolated rat hepatocytes was studied. Monobasic beta-lactam antibiotics such as apalcillin, cloxacillin, nafcillin, piperacillin, cefmetazole, cefoperazone, cefpiramide and cephalothin significantly inhibited the uptake of PCG, while amphoteric beta-lactam antibiotics such as amoxicillin, ...

The synthesis of cis-N-[a-carbobenzyloxy-b-(p-hydroxyphenyl)ethyl]-3-phthalimido-4-styryl-2-azetidinone is described. We have found that the electron-rich Schiff bases can afford the cis-b-lactam ring even in the presence of the free hydroxyl functions. The mechanisms of cis and trans-b-lactam ring formation are discuss...

Significant advances have been made in the structure-based engineering of enzymes useful for beta-lactam antibiotic production. Structure-based engineering of penicillin G acylase and cephalosporin acylase has resulted in improved enzymes for use in enzymatic production processes. The structures of many other enzymes that could be used in the production of beta-lactam antibiotics, such as enzym...

BACKGROUND AND OBJECTIVE Administration of carbapenems to β-lactam-allergic patients has always been considered potentially harmful because of a 47.4% rate of cross-reactivity to imipenem reported in a single study. Nevertheless, recent studies have shown that the rate of cross-reactivity of imipenem and meropenem with penicillins is lower than 1%. The aim of this study was to evaluate the poss...

the synthesis of cis-n-[a-carbobenzyloxy-b-(p-hydroxyphenyl)ethyl]-3-phthalimido-4-styryl-2-azetidinone is described. we have found that the electron-rich schiff bases can afford the cis-b-lactam ring even in the presence of the free hydroxyl functions. the mechanisms of cis and trans-b-lactam ring formation are discussed. the discussions are consistent with the recent publications.

We study a variable exponent model for image restoration in the case that the exponent attains the critical value one. We prove existence and Γ-convergence. The results answer an open question by Li, Li and Pi [Variable exponent functionals in image restoration, Appl. Math. Comput. 216 (2010), no. 3, 870–882].

Received (Day Month Year) Communicated by (xxxxxxxxxx) Let Ω be an open bounded set of R 3 and let W and V be two non-negative continuous functions vanishing at α, β and α ′ , β ′ , respectively. We analyze the asymptotic behavior as ε → 0, in terms of Γ-convergence, of the following functional Fε(u) := ε p−2 Z Ω |Du| p dx + 1 ε p−2 p−1 Z Ω W (u)dx + 1 ε Z ∂Ω V (T u)dH 2 (p > 2), where u is a s...