The envelope (E) protein from coronaviruses is a small polypeptide that contains at least one alpha-helical transmembrane domain. Absence, or inactivation, of E protein results in attenuated viruses, due to alterations in either virion morphology or tropism. Apart from its morphogenetic properties, protein E has been reported to have membrane permeabilizing activity. Further, the drug hexamethy...

Both short-term and long-term variations have been observed in measured friction on pavement surface. These variations have been attributed to different factors, such as traffic, rainfall and temperature. Due to the fact that Hot Mix Asphalt (HMA) pavement surface and rubber tires are viscoelastic materials, it is believed that temperature may affect the measured frictional properties. Some res...

BACKGROUND Understanding the excretion of 3,4-methylenedioxymethamphetamine (MDMA) and metabolites in sweat is vital for interpretation of sweat tests in drug treatment, criminal justice, and workplace programs. METHODS Placebo, low (1.0 mg/kg), and high (1.6 mg/kg) doses of oral MDMA were given double-blind in random order to healthy volunteers (n = 15) with histories of MDMA use. Participan...

Various models have been developed over the past several decades to predict the dynamic modulus /E*/ of hot-mix asphalt (HMA) based on regression analysis of laboratory measurements. The models most widely used in the asphalt community today are the Witczak 1999 and 2006 predictive models. Although the overall predictive accuracies for these existing models as reported by their developers are q...

Muscle wasting in old age or cancer may result from failed myofiber regeneration and/or accelerated atrophy. This study aimed to determine from transcriptomic analysis of human muscle the integrity of the cellular stress response system in relation to satellite cell differentiation or apoptosis in patients with cancer (weight-stable (CWS) or weight-losing (CWL)) or healthy elderly (HE) when com...

We investigated the effect of Brussels sprouts, inulin and a fermented milk on the faecal microbiota diversity of human microbiota-associated (HMA) rats by PCR-temporal temperature gradient gel electrophoresis (PCR-TTGE) using universal and group-specific 16S rRNA gene primers. The HMA rats were submitted to a control diet for 10 d (initial time), then switched to the experimental diets for 4 w...

A mutation has been identified that suppresses the mating and sporulation defects of all mutations in the mating-type loci of S. cerevisiae. This suppressor, sir1-1, restores mating ability to mat alpha 1 and mat alpha 2 mutants and restores sporulation ability to mat alpha 2 and mata1 mutants. MATa sir1-1 strains exhibit a polar budding pattern and have reduced sensitivity to alpha-factor, bot...

Abstract. Knowledge about the occurrence and characteristics of surge-type glaciers is crucial due to impact surging on glacier melt glacier-related hazards. One super-clusters High Mountain Asia (HMA). However, no consistent region-wide inventory in HMA exists. We present a regionally resolved based their behaviour across between 2000 2018. identify from surface velocity, elevation feature cha...