Arg-gingipain (Rgp) and Lys-gingipain (Kgp) are cysteine proteinases produced by Porphyromonas gingivalis, a major etiological bacterium of periodontal diseases. Here we show a series of small peptide analogs able to inhibit either Rgp or Kgp, which are synthesized on the basis of the cleavage site specificity of human salivary histatins by each enzyme. Among this series of compounds, carbobenz...

PURPOSE To study the effects of extended contact lens wear (EW) on the movement of basal epithelial cells toward the corneal surface. METHODS Rabbits (n = 32) were injected with 5-bromo-2-deoxyuridine (BrdU) to label a group of proliferating basal epithelial cells, and, 24 hours later, one randomly chosen eye was fitted with a low- or medium-oxygen-transmissible (Dk/t) rigid gas permeable (RG...

this study compared tear function tests and cytologic changes on the conjunctival surface in asymptomatic patients wearing contact lens of different materials. included in this study were 40 eyes wearing daily wear 4 week replacement hydrogel (h) lenses, 32 eyes wearing silicone hydrogel (sih) lenses, 18 eyes wearing rigid gas-permeable (rgp) lenses, and 21 healthy eyes (no lenses) as the contr...

In the framework of introducing green strategies for food processing, industrial orientation has shifted towards replacement conventional petroleum-based solvents with alternative eco-friendly ones. On this basis, objective study was to synthesize a novel, tertiary, food-grade deep eutectic solvent, composed glycerol, citric acid, and L-proline (GL-CA-Pro), test it as solvent extraction polyphe...