BACKGROUND Acetazolamide and medroxyprogesterone acetate (MPA) are two respiratory stimulants that can be used in patients with stable hypercapnic COPD. DESIGN AND METHODS The effects of acetazolamide, 250 mg bid, and MPA, 30 mg bid, on daytime and nighttime blood gas values and the influences on the hypercapnic and hypoxic ventilatory and mouth occlusion pressure (P(0.1)) at 100 ms response ...

s 34 transplant, pharmacokinetic data for MPA in this time. This discrepancy can be attributed to a 35% decline (P<0.01) of the free MPA fraction from 1.4% patient population are scarce and dosage guidelines are therefore preliminary. (range 0.6–5.1%) in the initial phase post-transplant to 0.9% (range 0.5–1.9%) in the stable phase. The decrease of the free MPA fraction is probably caused Metho...

Background: A routine phenotypic test has not been recommended for detection of metallo-β-lactamases (MBLs) producing Enterobacteriaceae species such as Escherichia coli. The current study was conducted to compare the 2-Mercaptopropionic acid (2-MPA) phenotypic method and ertapenem non-susceptibility test with polymerase chain reaction in predicting the production of MBLs in clinical isolates o...

abstract three pear genotypes (nazkeh, lasoreh and qevilah), grown in 2l containers, were studied under four irrigation regimes in order to evaluate the leaf relative water content (rwc), photosynthesis, leaf gas exchanges and plant dry weight induced by water stress. control treatment everyday was irrigation. irrigation was practiced when soil water potential reached at -0.4, -0.8, and -1.2 mp...

OBJECTIVE The objective of this study was to assess, in vitro, the influence of bleaching gel and the use of desensitizing agent over bond strength of ceramic brackets bonded to bovine enamel. METHODS One hundred bovine incisors were selected and randomly divided into five groups (n = 20): Group 1, control group (without bleaching); Group 2, bleached with 35% hydrogen peroxide; Group 3, bleac...

Mycophenolic acid (MPA) is a relatively new immunosuppressive drug, used since the nineties for the prevention of rejection in kidney transplantation. MPA has not only proved effective in preventing rejection, being even superior to azathioprine, but also seems to cause less adverse effects than other immunosuppressive drugs [1]. Because of these favourable experiences with MPA in renal transpl...

Several studies have demonstrated that endothelin-1 (ET-1) plays an important pathophysiological role in ischaemic renal failure and drug-induced renal injury, such as cyclosporine A (CsA)- and tacrolimus-associated nephrotoxicity. This study aimed to investigate whether the new immunosuppressive drug mycophenolic acid (MPA), which in contrast with CsA and tacrolimus lacks nephrotoxic side effe...

The diversity of deep-sea high-pressure-adapted (piezophilic) microbes in isolated monoculture remains low. In this study, a novel obligately psychropiezophilic bacterium was isolated from seawater collected from the Puerto Rico Trench at a depth of ∼6,000 m. This isolate, designated YC-1, grew best in a nutrient-rich marine medium, with an optimal growth hydrostatic pressure of 50 MPa (range, ...

BACKGROUND Hormone therapy (HT) after the menopause is associated with increased risk of venous thromboembolism (VTE). Tibolone has pharmacodynamic properties different from other hormone preparations. We compared the effect of a combined HT and tibolone on the inhibition of haemostasis. METHODS Thirty-eight post-menopausal women were randomly assigned to 1.25 or 2.5 mg per day of tibolone or...